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uchida_kawasaki
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Hiroshi Tsuji, MD, PhD, MPH🌏産業医
@Hiroshi_Tsuji
ウイルスが冬に強いのは主に湿度が低い事が原因。理由は3つ。遠くまで浮遊する、粘膜の状態が悪くなりウイルス排除難しくなる、免疫応答が抑制される。人は室内に90%の時間いるので室内環境が重要。ただししぶき飛ばす近距離や接触感染は別に予防必要。米イェール大教授指摘 news.yale.edu/2020/03/30/hop…
2020-04-09 06:50:03
Hiroshi Tsuji, MD, PhD, MPH🌏産業医
@Hiroshi_Tsuji
ウイルス性呼吸器感染症防止のためには湿度は40-60%が最も適切。先月ウイルス学の国際雑誌にウイルスと温度湿度の関係性のレビュー論文発表した米イェール大Iwasaki教授@VirusesImmunity がインタビューに答えてます。室内環境が重要で、比較的シンプルな対処なので目安に湿度管理すべきでしょう。
2020-04-26 12:00:21
Hiroshi Tsuji, MD, PhD, MPH🌏産業医
@Hiroshi_Tsuji
今朝のNewsweekにもアップデートされたエビデンスと共に新型コロナウイルス感染予防にベストな湿度は40-60%と出ました。米イェール大Iwasaki教授。newsweek.com/right-level-hu…
2020-06-03 22:25:062019年の論文
Low ambient humidity impairs barrier function and innate resistance against influenza infection | PNAS https://www.pnas.org/content/116/22/10905
周囲湿度が低いと、インフルエンザ感染に対するバリア機能と先天性耐性が損なわれます
Prof. Akiko Iwasaki
@VirusesImmunity
As we approach the cold winter months in the Northern Hemisphere, I want to share these movies of mucociliary clearance (MCC) in the trachea of mice housed at 10% vs. 50% relative humidity (RH). Captured by @ericsongg (1/n) This is MCC at 50% RH 👇🏽 pic.twitter.com/te5UKxIz4h
2020-10-26 03:22:55
Prof. Akiko Iwasaki
@VirusesImmunity
And here is MCC of mice kept at 10% RH 👇🏽 For more, please read our original paper. pnas.org/content/116/22… (2/n) pic.twitter.com/e9Pyu7J6Sq
2020-10-26 03:22:57
Prof. Akiko Iwasaki
@VirusesImmunity
MCC is a key mechanism of removal of inhaled particles, including viruses and bacteria. It is a primary defense mechanism of the respiratory tract. The dry air dehydrates the mucus and periciliary layer, impairing MCC. (3/n) annualreviews.org/doi/abs/10.114… pic.twitter.com/fTNjgIlC1O
2020-10-26 03:22:59
拡大
Prof. Akiko Iwasaki
@VirusesImmunity
The impact of humidity on MCC is quite striking 👆🏽 Indoor RH during winter can drop dangerously low. Let’s humidify our homes. As for public buildings, please sign our petition to the WHO to set guidance on humidity to combat respiratory infection. (End) 40to60rh.com
2020-10-26 03:23:00換気も重要
Prof. Jose-Luis Jimenez
@jljcolorado
@VirusesImmunity Prof. Iwasaki, another strategy is to filter the air (w/ HEPA filters or cheap fan+filter) to remove the virus from the air. Given limited funds, & also lower maintenance (need to constantly refill water reservoirs, easy to forget), we have been recommending that over humidifying
2020-10-26 04:19:01
Prof. Jose-Luis Jimenez
@jljcolorado
@VirusesImmunity For example in tinyurl.com/faqs-aerosol (where we do also mention the effect of humidity on ease of infection as in your data) Do you have a comment on that?
2020-10-26 04:19:22結露が心配
Erin C. Sanders, MSN, WHNP-BC (She/Her)
@ErinSandersNP
@VirusesImmunity I feel like there will be a significant struggle to balance the risks of the general public not cleaning the humidifiers adequately or often enough leading to decreased air quality/mold exposure vs viral susceptibility d/t dehydrated mucosa. Are air purifiers a better investment?
2020-10-26 04:21:31
Prof. Akiko Iwasaki
@VirusesImmunity
@ErinSandersNP Since they’re important for different reasons I would recommend both.
2020-10-26 04:27:29
Erin C. Sanders, MSN, WHNP-BC (She/Her)
@ErinSandersNP
@VirusesImmunity @VirusesImmunity I just keep thinking of the people who can’t afford either. How they likely live in environments that are less healthy at baseline. Humidifiers are cheaper than HEPA but if mold is already growing in the home it could worsen the problem & strain the immune system
2020-10-26 04:39:57
Bob Kurbel
@BobKurbel
@ErinSandersNP @VirusesImmunity In climates where it can reach (-10 ) — (-20 F ) at night the ideal indoor humidity is 35% to 40% Higher values than that are not only very difficult to reach but will cause heavy condensation on windows and outside walls leading to mold issues
2020-10-26 06:55:32マスクにも加湿効果？
Shawna Reed
@profpathogen1
@VirusesImmunity Question; do masks increase the effective RH in airways of mask wearers? certainly they have moisturized my facial skin while wearing >20h per week for the past few months.
2020-10-26 04:31:32
Prof. Akiko Iwasaki
@VirusesImmunity
@profpathogen1 I think so! This could be yet another benefit of wearing masks. Masks can 1) reduce viral transmission 2) humidify respiratory tract 3) warm your nose to enhance innate immunity to viruses 🦠
2020-10-26 04:35:43私はそう思う！
これは、マスクを着用することのさらに別の利点である可能性があります。 マスクは以下の効果がある可能性。
1）ウイルス感染を減らす
2）気道を加湿する
3）鼻を温めて、ウイルスに対する自然免疫を強化します
mannie akizuki
@mannie_ub
気道粘膜のウィルス除去機能(MCC)と相対湿度(岩崎教授): RH50%、10%の比較、マウスを使った動画。冬は換気に加え、加湿と暖気も重要。 twitter.com/VirusesImmunit…
2020-10-26 07:50:25
Hiroshi Tsuji, MD, PhD, MPH🌏産業医
@Hiroshi_Tsuji
冬に向けて湿度管理が重要。米イェール大Iwasaki教授がマウスの気管粘液線毛クリアランスが相対湿度50→10%で低下する動画up。同氏は5月論文で、相対湿度が低いと粘液線毛クリアランス以外にも生来の抗ウイルス防御、および組織修復が損なわれる事を発表。 冬に向け40-60%へ湿度管理を勧めています。 twitter.com/virusesimmunit…
2020-10-26 08:01:41
Hiroshi Tsuji, MD, PhD, MPH🌏産業医
@Hiroshi_Tsuji
湿度を40-60%を勧める理由は免疫応答以外にもある。ウイルスの膜の崩壊が早い。膜を持つウイルスの殆どがこの湿度に弱い。60%超は勧めないカビが生えるから。また、90%超えると逆にウイルスは生存し易くなる。40-60%はスイートスポットであるとバージニア工科大Linsey Marr教授。 twitter.com/linseymarr/sta…
2020-10-27 06:11:13
Linsey Marr
@linseymarr
Signed. Not only because of a stronger immune response at mid-range relative humidity (40-60% RH) but also because of faster decay of SARS-CoV-2 and other enveloped viruses. twitter.com/VirusesImmunit…
2020-10-26 06:16:28
Linsey Marr https://www.threads.net/@linseycmarr
@linseymarr
Signed. Not only because of a stronger immune response at mid-range relative humidity (40-60% RH) but also because of faster decay of SARS-CoV-2 and other enveloped viruses. twitter.com/VirusesImmunit…
2020-10-26 06:16:28