Hartmut M
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- いいね！0
Seiichi Ushikubo
@sushikubo
@myen メモ: PTC1 consists of the fusion of the RET TK domain with a part of the H4 gene
2012-10-07 09:16:52
Seiichi Ushikubo
@sushikubo
@myen メモ: In PTC2, the RET TK domain is fused to the regulatory subunit RIa of the cAMP-dependent protein kinase A.
2012-10-07 09:18:12
Seiichi Ushikubo
@sushikubo
@myen メモ: In PTC3, RET is connected with the NH2-terminal part of ELE1 , .. identified as transcription coactivator of the androgen receptor
2012-10-07 09:20:19
Seiichi Ushikubo
@sushikubo
@myen メモ: "it is indeed the ELE1/RET genotype that generates the histological pattern of a solid variant of PTC."
2012-10-07 10:01:05
Seiichi Ushikubo
@sushikubo
@myen メモ: "PTCs with other types of rearrangement show a papillar or follicular growth pattern, as was also observed in .. H4/RET .. mice"
2012-10-07 10:03:45
Seiichi Ushikubo
@sushikubo
@myen メモ: "Thyroid carcinomas in H4/RET transgenic mice progress slowly and do not metastasize,"
2012-10-07 10:05:12
Seiichi Ushikubo
@sushikubo
@myen メモ: ".. whereas in ELE1/RET transgenic mice, metastatic potential of thyroid tumors has been observed."
2012-10-07 10:05:59
Seiichi Ushikubo
@sushikubo
@myen メモ: "The data show that a young age at irradiation does not favor a specific type of gene rearrangement."
2012-10-07 10:08:34
Seiichi Ushikubo
@sushikubo
@myen メモ: "This reflects the rapid growth of PTCs harboring an ELE1/RET rearrangement rather than a young age at irradiation."
2012-10-07 10:11:39
Seiichi Ushikubo
@sushikubo
@myen メモ: "the genetic spectrum shifts toward H4/RET rearrangements with increasing time after Chernobyl, ..."
2012-10-07 10:13:27
Seiichi Ushikubo
@sushikubo
@myen メモ: ",, later occurring tumors more frequently contained an H4/RET rearrangement."
2012-10-07 10:14:18
Seiichi Ushikubo
@sushikubo
@myen 以上、Hartmut M. (2000) Pattern of Radiation-induced RET and NTRK1 Rearrangements in 191 Post-Chernobyl Papillary Thyroid Carcinomas から引用
2012-10-07 10:20:42
Seiichi Ushikubo
@sushikubo
@myen Hartmut M. (2000) Pattern of Radiation-induced RET and NTRK1 Rearrangements .. http://t.co/aLUzh4ua
2012-10-07 10:23:58
Seiichi Ushikubo
@sushikubo
@myen Hartmut M. (2000) Tab.2 RET and NTRK1 rearrangements: 62.3% showed RET rearrangements (2/3: PTC3 and 1/4: PTC1) http://t.co/4XIJMh09
2012-10-07 13:13:33
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Seiichi Ushikubo
@sushikubo
@myen Hartmut M. (2000) Tab.3 ".. higher prevalence of rearrangement-positive tumors in faster developing PTCs", "ELE1/RET .. fastest"
2012-10-07 13:20:13
Seiichi Ushikubo
@sushikubo
@myen Hartmut M. (2000) Tab4 "..the age at radiation exposure lacks relation to a specific type of gene rearrangement." http://t.co/VhJP5JJ2
2012-10-07 13:28:58
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Seiichi Ushikubo
@sushikubo
@myen Hartmut (2000) Tab5: ELE1/RET is not characteristic to young age per se, but is typical for a short tumor latency http://t.co/LOqlZ6W2
2012-10-07 13:30:09
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Seiichi Ushikubo
@sushikubo
@myen Hartmut (2000) Fig2 "A higher dose appeared to produce more ELE1/RET rearrangements than H4/RET rearrangements" http://t.co/PcMoXaRa
2012-10-07 13:35:14
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Seiichi Ushikubo
@sushikubo
@myen Hartmut (2000) Fig3 "ELE1/RET .. speed up progression not only .. rearrangement-negative, but also .. H4/RET .." http://t.co/7kr6NSEd
2012-10-07 13:42:11
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Seiichi Ushikubo
@sushikubo
@myen Hartmut (2000) Tab7: "ELE1/RET .. show a clear connection to the histological type of the solid variant of PTC" http://t.co/odG9lMyo
2012-10-07 13:44:36
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Seiichi Ushikubo
@sushikubo
@myen Hartmut M. (2000) Tab.3 (画像追加) http://t.co/uDjw6J46
2012-10-07 13:49:03
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Seiichi Ushikubo
@sushikubo
@myen Hartmut M. (2000) Fig. 1: Prevalence of gene rearrangements as a function latency period. http://t.co/9eEZzODr
2012-10-07 13:52:07
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