2013年1月25日

UNSCEAR 2012 white paper

UNSCEAR 2012 BIOLOGICAL MECHANISMS OF RADIATION ACTIONS AT LOW DOSES A white paper to guide the Scientific Committee’s future programme of work Evaluating radiation science for informed decision-making からの抜粋
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UNSCEAR A/67/46
Report of the United Nations Scientific Committee on the Effects of Atomic Radiation
Fifty-ninth session

Chapter II
Deliberations of the United Nations Scientific Committee on the Effects of Atomic Radiation at its fifty-ninth session

B. Present programme of work

6. Biological mechanisms of radiation actions at low doses

  1. The document concludes that understanding of the mechanisms of so-called non-targeted and delayed effects is improving and that there is some evidence for differential responses in gene and protein expression for high- and low-dose radiation exposures, but there is a lack of consistency and coherence among reports. There is as yet no indication of a causal association of those phenomena with radiation-related disease. With regard to immune response and inflammatory reactions, there is a clearer association with disease, but there is no consensus on the impact of radiation exposure, particularly at low doses, on those physiological processes. While the document focuses on mechanisms relevant to carcinogenesis, some of the processes considered may be relevant for tissue reactions, and improved understanding may therefore be helpful for assessing the potential risk of non- cancer diseases at low and protracted exposures.

UNSCEAR 2012
BIOLOGICAL MECHANISMS OF RADIATION ACTIONS AT LOW DOSES
A white paper to guide the Scientific Committee’s future programme of work
Evaluating radiation science for informed decision-making

Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: BIOLOGICAL MECHANISMS OF RADIATION ACTIONS AT LOW DOSES. white paper to .. future programme of work http://t.co/cIkiEGhB

2013-01-21 00:47:30

(簡潔な要約としての図:non-targeted and delayed effects の最近の知見とその位置づけ)

Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012 white paper: Figure I. The (a) conventional and (b) systems views of radiation carcinogenesis http://t.co/UPwohHKQ

2013-01-21 01:03:45
拡大
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012 white paper: Figure I. The (a) conventional and (b) systems views of radiation carcinogenesis http://t.co/qVHwUq16

2013-01-21 01:02:19
拡大

The conventional view: targeted DNA mutations in stem cells (従来の考え方:幹細胞の直接的なDNA変異)
The systems view: considers the tissue context in which target/stem cells reside and intercellular/bystander signalling (システムとしての考え方:non-targeted and delayed effects を加味)

Seiichi Ushikubo @sushikubo

UNSCEAR Biological_mechanisus_WP_12-57831 (Paragraph-4) 外挿ではなく "Interpolating the dose–response" できると考えているんだな。

2013-01-21 01:47:37

V. CONCLUSIONS AND RECOMMENDATIONS

Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012 white paper: (60) "these reports remain mixed in outcome and there is little of the coherence required of robust data .."

2013-01-21 00:49:51
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012 white paper: (60) ".. that can be used confidently for risk assessment."

2013-01-21 00:50:30
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012 white paper: (60) "there is as yet no indication of a causal association of non-targeted phenomena .."

2013-01-21 00:51:54

(現時点ではリスク評価をするのに十分な non-targeted and delayed effects についてのデータが揃っていない)

Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: (61) "In the case of radiation-induced perturbation of immune function or induction of inflammatory reactions, ..

2013-01-21 00:53:33
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: (61) ".. (a) continue to encourage research into the mechanistic understanding of low-dose radiation action .."

2013-01-21 00:56:19
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: (61) ".. that may contribute to improved understanding of disease risk .. and into the factors that can modulate risk;"

2013-01-21 00:57:10
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: (61) ".. (b) consider developing further biologically based risk models and the systems- level framework .."

2013-01-21 00:58:26
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: (61) ".. to integrate mechanistic data into a risk assessment framework;"

2013-01-21 00:59:04
Seiichi Ushikubo @sushikubo

@myen UNSCEAR 2012: (61) ".. there is a clearer association with disease but the impact of radiation is less well understood."

2013-01-21 00:54:11

(生物学的なアプローチからのリスク評価への期待)

II. BACKGROUND

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