臨床試験について書く（読む）ときの注意点１０

s_matashiro @glasscatfish

世界科学ジャーナリスト会議での講演：論文の取り下げやブログによる指摘、科学者や雑誌の対応など：Can We Still Trust Science? on @slideshare #fraud #misconduct http://t.co/0iTeNwIVuG

s_matashiro @glasscatfish

世界科学ジャーナリスト会議というのがヘルシンキでやってるようだ。 その関連でRuth Francisさんが、臨床試験について書くときの注意点１０をツイート １）臨床試験の登録日に注意 https://t.co/PnvGTjFpYv https://t.co/TSoaz1kBRD

Ruth Francis @Roobina

Right people. Are you ready for a mega 10 tweets?? Here goes. Ten top tips for reporting #trials #wcsj2013

Ruth Francis @Roobina

1/10 Was this #trial registered before it began? If not then check for rigged design, or hidden negative results on similar trials #wcsj2013

s_matashiro @glasscatfish

@glasscatfish ２）主要な結果を試験プロトコールと論文間で比較せよ https://t.co/x7OewDiQJL ３）いいとこ取りしてないかは他の試験と比較 https://t.co/FoosAfZeoJ

Ruth Francis @Roobina

2/10 Is primary outcome reported in paper the same as primary outcome spec in protocol? If no report maybe deeply flawed #trials #wcsj2013

Ruth Francis @Roobina

3/10 Look for other trials by co or group, or on treatment, on registries to see if it represents cherry picked finding #wcsj2013 #trials

s_matashiro @glasscatfish

@glasscatfish ４）「常に」試験の主体に言及せよ https://t.co/wuzNLniUMD ５）その臨床試験は、試験が行われた国にとって有用なのか？ https://t.co/6rjKbATTzM ６）参加者数 https://t.co/GTLszfO4qE

Ruth Francis @Roobina

4/10 ALWAYS mention who funded the trial. Do any of ethics committee people have some interest with the funding company #trials #wcsj2013

Ruth Francis @Roobina

5/10 Will country where work is done benefit? Will drug be available at lower cost? Is disorder or disease a problem there #trials #wcsj2013

Ruth Francis @Roobina

6/10 How many patients were on the trial, and how many were in each arm? #trials #wcsj2013

s_matashiro @glasscatfish

@glasscatfish ７）比較しているのは偽薬と？既存薬と？ https://t.co/yn2kByklJO ８）恩恵を受けるのはどういう患者か（病気の種類や段階）正確に https://t.co/jcspyHriwi

Ruth Francis @Roobina

7/10 What was being compared (drug vs placebo? Drug vs standard care? Drug with no control arm?) #trials #wcsj2013

Ruth Francis @Roobina

8/10 Be precise about people/patient who benefited – advanced disease, a particular form of a disease? #trials #wcsj2013

s_matashiro @glasscatfish

@glasscatfish ９）頻度の表現は％を使わずに、10万人あたりの数など自然な表現で https://t.co/MWaabrLssj １０）相対的なリスクの表現はダメ。「３％長生き」より、「平均２ヶ月」 https://t.co/UaA1N2a3It

Ruth Francis @Roobina

9/10 Report natural frequencies: “13 people per 10000 experienced x”, rather than “1.3% of people experienced x” #trials #wcsj2013

Ruth Francis @Roobina

10/10 NO relative risks. Paint findings clearly: improved survival by 3%: BAD. Ppl lived 2 months longer on average: GOOD #trials #wcsj2013

うさじま うさこ @usausa1975

@glasscatfish 「書くとき」だけじゃなくて、読むときにも参考になりますね~。

s_matashiro @glasscatfish

@usausa1975 この５番目があまり意識してない視点でした。