【iMuSCs細胞】~STAP細胞とSTAP現象を巡る混乱~
2015年11月27日に公開された問題の論文
@ShinHiroi 引用文献:Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells nature.com/articles/srep1…
2015-12-12 17:13:23小保方氏の論文がどこで引用されたか?
具体的にはDiscussionの冒頭部分。
@ShinHiroi The existence of pluripotent-like cells in adult tissues has been a matter of debate for years,
2015-12-12 17:08:26@ShinHiroi since inconsistent results have been reported by various groups9,10,11,12,13,14,15
2015-12-12 17:09:08@ShinHiroi 色々なグループが分化した組織が多能性を取り戻すような現象が起こり得るか議論している。の13番目の引用文献。
2015-12-12 17:11:15この論文が引用された。
新薬たん注;STAP現象の裏付けとして引用されたのでは無い。「色々な議論がある」という1例で小保方氏の論文が引用された。
@ShinHiroi Obokata, H. et al. The potential of stem cells in adult tissues representative of the three germ layers ncbi.nlm.nih.gov/pubmed/2088311…
2015-12-12 17:12:16申し訳ありません。致命的な引用ミスが見つかったので訂正します。
『The existence of pluripotent-like cells in adult tissues has been a matter of debate for years, since inconsistent results have been reported by various groups9,10,11,12,13,14,15; however, no study thus far has proven that such pluripotent stem cells can arise from differentiated somatic tissues.』
後半部、howeverから、「しかし、どの研究も多能性幹細胞は分化した身体組織から発生する可能性を証明していない」
*今回発表されたiMuSCs細胞に関する論文
『Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells』の解説*
イントロダクションを全文訳しました。(新薬たん訳)
@ShinHiroi Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells
2015-12-12 14:32:36@ShinHiroi We recently discovered a novel population of stem cells from the injured murine skeletal muscle
2015-12-12 14:37:10@ShinHiroi These injury induced muscle-derived stem cell-like cells (iMuSCs) are partially reprogrammed from differentiated myogenic
2015-12-12 14:40:18@ShinHiroi The iMuSCs exhibit stem cell properties including the ability to differentiate into multiple lineages,
2015-12-12 14:45:59@ShinHiroi they also display a superior migration capacity that demonstrating a strong ability of muscle engraftment in vivo.
2015-12-12 14:51:26@ShinHiroi IMuSCs express several pluripotent and myogenic stem cell markers; have the capability to form embryoid bodies and teratomas,
2015-12-12 14:54:56