Epistasis

Yaniv Erlich 💔 @erlichya

@dgmacarthur @ewanbirney I agree with your view but here is a rebuttal against the previous one: journals.plos.org/plosgenetics/a…

Ewan Birney @ewanbirney

@dgmacarthur @erlichya Rather than statistical vs molecular, how about "important for understanding human genetics"

Ewan Birney @ewanbirney

@dgmacarthur I like this, but don't you find it odd that these variance models (explaining say 80% of genetic var) are not good predictors?

Ewan Birney @ewanbirney

@dgmacarthur The out-of-sample prediction being poor from the global genomic model suggests to me that there something askew

Yaniv Erlich 💔 @erlichya

@ewanbirney @dgmacarthur both important but for different things.

Ewan Birney @ewanbirney

@dgmacarthur I've never had a satisfactory answer why these models work well for *prediction* in (say) cattle but not in human outbreds

Ewan Birney @ewanbirney

For the aficionados, notice that the last two papers tweeted by @erlichya @dgmacarthur came from the Edinbrugh quantitative genetics groups

Ewan Birney @ewanbirney

For the aficionados, notice that the last two papers tweeted by @erlichya @dgmacarthur came from the Edinbrugh quantitative genetics groups

Ewan Birney @ewanbirney

Two poorly appreciated things in my view: the current variance models/GCTA/Vissher in human comes from the animal and plant breeding world

Ewan Birney @ewanbirney

Two poorly appreciated things in my view: the current variance models/GCTA/Vissher in human comes from the animal and plant breeding world

Kevin Mitchell @WiringTheBrain

.@pnin1957 @smomara1 It's amazing to me that you don't seem to think there are any environmental differences within societies.

Kevin Mitchell @WiringTheBrain

.@pnin1957 @smomara1 It's amazing to me that you don't seem to think there are any environmental differences within societies.

Ewan Birney @ewanbirney

Secondly in the 80s and 90s this strand of theory almost died out as people moved into mendelian genetics, positional cloning etc

Ewan Birney @ewanbirney

Secondly in the 80s and 90s this strand of theory almost died out as people moved into mendelian genetics, positional cloning etc

Kevin Mitchell @WiringTheBrain

.@JayMan471 @ewanbirney No they don't. Can't tell additive from non-additive just by twin design. Too many parameters, too few measures

Kevin Mitchell @WiringTheBrain

.@JayMan471 @ewanbirney No they don't. Can't tell additive from non-additive just by twin design. Too many parameters, too few measures

Ewan Birney @ewanbirney

We should be thankful that Edinburgh (and other places) kept the old school quantitative genetics flame alive....

Ewan Birney @ewanbirney

We should be thankful that Edinburgh (and other places) kept the old school quantitative genetics flame alive....

Ewan Birney @ewanbirney

@KMS_Meltzy @OmicsOmicsBlog Ha. Come to the plant and fungi world if you want to see the true mean of ploidy headaches...