Nikiforov YE (2011)

Seiichi Ushikubo @sushikubo

Nikiforov YE. Molecular analysis of thyroid tumors. Modern Pathology (2011) 24, S34–S43 http://t.co/u2VH4gIK (甲状腺がんの原因遺伝子の点変異/再構成についてのレビュー)

Seiichi Ushikubo @sushikubo

@myen Nikiforov YE. (2011) "Four mutation types, that is, BRAF and RAS point mutations and RET/PTC and PAX8/PPARg rearrangements, ..."

Seiichi Ushikubo @sushikubo

@myen Nikiforov YE. (2011) "Papillary carcinomas harbor point mutations of the BRAF and RAS genes and RET/PTC rearrangements, ..."

Seiichi Ushikubo @sushikubo

@myen Nikiforov YE. (2011) "... all of which are able to activate the mitogen-activated protein kinase (MAPK) pathway."

Seiichi Ushikubo @sushikubo

@myen Nikiforov YE. (2011) "These mutually exclusive mutations are found in 70% of papillary thyroid carcinomas."

Seiichi Ushikubo @sushikubo

@myen Nikiforov YE. (2011) "Mutations of the BRAF gene have been reported in 35–70% of papillary thyroid carcinomas, ..."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "The vast majority (>95%) of BRAF mutations found in thyroid cancer are a T1799A leading to a substitution of V600E"

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "BRAF V600E mutation has .. been shown to correlate with .. aggressive characteristics of papillary carcinomas, .."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "RET/PTC: Two most common rearrangement types, RET/PTC1 and RET/PTC3, .."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "RET/PTC chimeric protein to activate the RAS–RAF–MAPK cascade and initiate thyroid tumorigenesis."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "RET/PTC rearrangements are found on average in 10–20% of adult sporadic papillary carcinomas, .."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "RET/PTC occur with higher incidence in patients with the history of radiation exposure (50–80%) ..."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "The distribution of RET/PTC rearrangement within tumor cells can vary from clonal RET/PTC to nonclonal RET/PTC"

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "In papillary thyroid carcinomas, RET/PTC1 is the most common and comprises 60–70% .. , RET/PTC3 accounts for 20–30%

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "Among papillary carcinomas in children exposed to radiation after the Chernobyl accident, ...(cont)"

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "(cont).. a strong correlation between different RET/PTC types and morphological variants of papillary carcinoma .."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "However, it remains unclear whether such phenotype–genotype correlation exists in the general population."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "Point mutations of the RAS gene are not restricted to a particular type of thyroid tumors, .."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "Papillary carcinomas harboring RAS mutation almost always have the follicular variant histology, .."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "this mutation(RAS) also correlates with .. more frequent encapsulation, and low rate of lymph node metastases."

Seiichi Ushikubo @sushikubo

@myen Nikiforov (2011) "In papillary carcinomas, RAS mutations occur in 15–20% of tumors."

Seiichi Ushikubo @sushikubo

Nikiforov YE. (2011) Fig. 3 Diagnostic significance of mutational testing in thyroid FNA .. http://t.co/u2VH4gIK http://t.co/vY7xGpFA

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