-
- いいね！0
Kevin Mitchell
@WiringTheBrain
.@ewanbirney No - model just says when have N alleles you're fine, but N+1 (or small number) and you're diseased. Purely genetic threshold
2016-02-10 19:11:27
Kevin Mitchell
@WiringTheBrain
.@AndrewSabisky @Abebab Yes, in theory could be an interaction. But trends over time w/in pop'ns => envt'l diffs most important
2016-02-10 19:14:05
Kevin Mitchell
@WiringTheBrain
.@AndrewSabisky @Abebab Yes, in theory could be an interaction. But trends over time w/in pop'ns => envt'l diffs most important
2016-02-10 19:14:05
Kevin Mitchell
@WiringTheBrain
.@AndrewSabisky @Abebab Have same thing with Flynn effect. Far too rapid a change in IQ w/in pop'ns for it to be genetic
2016-02-10 19:14:46
Kevin Mitchell
@WiringTheBrain
.@AndrewSabisky @Abebab Have same thing with Flynn effect. Far too rapid a change in IQ w/in pop'ns for it to be genetic
2016-02-10 19:14:46
Kevin Mitchell
@WiringTheBrain
.@AndrewSabisky Emphasises point that heritability is not a fixed biological constant but a relative measure just in population tested
2016-02-10 19:15:48
Kevin Mitchell
@WiringTheBrain
.@AndrewSabisky Emphasises point that heritability is not a fixed biological constant but a relative measure just in population tested
2016-02-10 19:15:48
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab No, not really. Mean diffs b/w pop'ns could be entirely environmental, even with high h2: pic.twitter.com/8IOFXV3ePi
2016-02-10 19:28:09
拡大
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab No, not really. Mean diffs b/w pop'ns could be entirely environmental, even with high h2: pic.twitter.com/8IOFXV3ePi
2016-02-10 19:28:09
拡大
Kevin Mitchell
@WiringTheBrain
Yes, this makes the point nicely. Environmental diffs across Europe masked genetic effects on body mass index twitter.com/StuartJRitchie…
2016-02-10 19:29:37
Kevin Mitchell
@WiringTheBrain
Yes, this makes the point nicely. Environmental diffs across Europe masked genetic effects on body mass index twitter.com/StuartJRitchie…
2016-02-10 19:29:37
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab No. Low h2 => group diffs prob not genetic. High h2 => they could be, but doesn't give a probability. At all.
2016-02-10 19:47:44
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab No. Low h2 => group diffs prob not genetic. High h2 => they could be, but doesn't give a probability. At all.
2016-02-10 19:47:44
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab Really? Large environmental diffs are rare outside the lab?!? What utopia are you living in?
2016-02-10 19:48:35
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab Really? Large environmental diffs are rare outside the lab?!? What utopia are you living in?
2016-02-10 19:48:35
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab Doesn't have to be perfect. Have large average envt'l diffs b/w pop'ns, b/w groups (by SES for example) and over time
2016-02-10 19:59:31
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab Doesn't have to be perfect. Have large average envt'l diffs b/w pop'ns, b/w groups (by SES for example) and over time
2016-02-10 19:59:31
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab Average environmental differences can show up in group average phenotypic differences, exactly what is under discussion
2016-02-10 20:00:20
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @Abebab Average environmental differences can show up in group average phenotypic differences, exactly what is under discussion
2016-02-10 20:00:20
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @smomara1 Here's another. Avg IQ in Ireland in 1970: ~85. By 2000: >100. Not genetic. Likely due to urbanisation/better education
2016-02-10 20:10:36
Kevin Mitchell
@WiringTheBrain
.@pnin1957 @smomara1 Here's another. Avg IQ in Ireland in 1970: ~85. By 2000: >100. Not genetic. Likely due to urbanisation/better education
2016-02-10 20:10:36
Ewan Birney
@ewanbirney
@jcbarret @leonidkruglyak @dgmacarthur Please show your working :)
2016-02-10 20:59:32
Daniel MacArthur
@dgmacarthur
@ewanbirney This is old, but greatly influenced my thinking on epistasis: journals.plos.org/plosgenetics/a…
2016-02-10 21:17:23
Yaniv Erlich 💔
@erlichya
@dgmacarthur @ewanbirney Ewan, do you refer to statistical epistasis or molecular epistasis?
2016-02-10 21:19:52
Daniel MacArthur
@dgmacarthur
@erlichya @ewanbirney I assumed statistical; that's where the debate is.
2016-02-10 21:21:09