@dgmacarthur @ewanbirney I agree with your view but here is a rebuttal against the previous one: journals.plos.org/plosgenetics/a…
2016-02-10 21:27:56@dgmacarthur @erlichya Rather than statistical vs molecular, how about "important for understanding human genetics"
2016-02-10 21:52:12@dgmacarthur I like this, but don't you find it odd that these variance models (explaining say 80% of genetic var) are not good predictors?
2016-02-10 21:53:39@dgmacarthur The out-of-sample prediction being poor from the global genomic model suggests to me that there something askew
2016-02-10 21:54:26@ewanbirney @dgmacarthur both important but for different things.
2016-02-10 21:55:13@dgmacarthur I've never had a satisfactory answer why these models work well for *prediction* in (say) cattle but not in human outbreds
2016-02-10 21:55:17For the aficionados, notice that the last two papers tweeted by @erlichya @dgmacarthur came from the Edinbrugh quantitative genetics groups
2016-02-10 21:58:28For the aficionados, notice that the last two papers tweeted by @erlichya @dgmacarthur came from the Edinbrugh quantitative genetics groups
2016-02-10 21:58:28Two poorly appreciated things in my view: the current variance models/GCTA/Vissher in human comes from the animal and plant breeding world
2016-02-10 21:59:13Two poorly appreciated things in my view: the current variance models/GCTA/Vissher in human comes from the animal and plant breeding world
2016-02-10 21:59:13.@pnin1957 @smomara1 It's amazing to me that you don't seem to think there are any environmental differences within societies.
2016-02-10 21:59:25.@pnin1957 @smomara1 It's amazing to me that you don't seem to think there are any environmental differences within societies.
2016-02-10 21:59:25Secondly in the 80s and 90s this strand of theory almost died out as people moved into mendelian genetics, positional cloning etc
2016-02-10 21:59:58Secondly in the 80s and 90s this strand of theory almost died out as people moved into mendelian genetics, positional cloning etc
2016-02-10 21:59:58.@JayMan471 @ewanbirney No they don't. Can't tell additive from non-additive just by twin design. Too many parameters, too few measures
2016-02-10 22:00:07.@JayMan471 @ewanbirney No they don't. Can't tell additive from non-additive just by twin design. Too many parameters, too few measures
2016-02-10 22:00:07We should be thankful that Edinburgh (and other places) kept the old school quantitative genetics flame alive....
2016-02-10 22:00:43We should be thankful that Edinburgh (and other places) kept the old school quantitative genetics flame alive....
2016-02-10 22:00:43@KMS_Meltzy @OmicsOmicsBlog Ha. Come to the plant and fungi world if you want to see the true mean of ploidy headaches...
2016-02-10 22:03:03