posts aggrigation for "The biology of genomes" (1)

Chris Cotsapas @ccots

Opt-out policy preferable? #bg2011

Larry Parnell @larry_parnell

Most if not all of KG's slides on C elegans embryogenesis networks refer to published material. #BG2011

India Hook-Barnard, PhD @SelectAgent

Thanks! MT @lukejostins @dgmacarthur: Biology of Genomes 2011 about to start. Tweeting permission allowing, of course. #BG2011

Deniz Kural @denizkural

#bg2011 15K insect genomes: The Arthropod Genomic Consortium http://bit.ly/irREUY

Shoa L. Clarke @ShoaClarke

Watching live feed of #BG2011

Shoa L. Clarke @ShoaClarke

@dgmacarthur Did Andy mention rules for people watching live feed? I tuned in a little late. #BG2011

Larry Parnell @larry_parnell

Barak Cohen on cis-regulatory elements in mammalian cells, #BG2011

Daniel MacArthur @dgmacarthur

We are all shocked - shocked! - to see @ewanbirney take the mike for the first question of the meeting. #bg2011

Daniel MacArthur @dgmacarthur

@ShoaClarke Not specifically, but I think we can assume the tweetability rules apply to remote viewers as well. #bg2011

Orli Bahcall @obahcall

First night of CSHL Biology of Genomes kicks off with session on high throughput genetics and genomics and review of tweeting policy.#bg2011

Luke Jostins-Dean @lukejostins

And we're off: Barak Cohen has okayed tweeting about his talk about combinatorial cis-Regulation #BG2011

Daniel MacArthur @dgmacarthur

Barak Cohen: we know a huge amount about gene expression, but still can't predict levels from sequence. Why not? #bg2011

Luke Jostins-Dean @lukejostins

Combinatorial cis-regulation is non-additive interaction of regulatory elements. Complex stuff but lots of new data #BG2011

Chris Cotsapas @ccots

“@larry_parnell: Most if not all of KG's slides on C elegans embryogenesis networks refer to published material. #BG2011” but not tweetable

Daniel MacArthur @dgmacarthur

BC: the problem is statistical: the combinatorial complexity of transcription factors is overwhelming #bg2011

Chris Cotsapas @ccots

#bg2011 love model organisms. Make it all look easy.

Luke Jostins-Dean @lukejostins

BC: Genome contains only a tiny sampling of all possible TF binding site combinations. So create sythetic promotors. #BG2011

Chris Cotsapas @ccots

#bg2011 BC thermodynamic model of TFs binding to DNA. But TF/DNA Ka drops off exponentially with variation. Pop var?

Luke Jostins-Dean @lukejostins

BC: Sythetic promotors are toy examples with mixes of TFs. Thermodynamic model explains 75% of expression variation #BG2011

Daniel MacArthur @dgmacarthur

BC showing a beautiful model system for testing thousands of synthetic promoters, using barcoded reporter genes. #bg2011

tgenahmet @tgenahmet

Done with 1000 genomes. Now in #bg2011. This place is filled with tweeters.

Luke Jostins-Dean @lukejostins

BC: But more TFs require more data. So incorporate barcodes into the reporter gene, and do pooled nex-gen sequencing #BG2011

Shoa L. Clarke @ShoaClarke

BC premise is that f(seq)=expression is not a simple linear function but then he goes on to model as a linear function :P #BG2011

Aoife McLysaght @aoifemcl

In Cold Spring Harbor, NY for #BG2011. Fighting jet-lag. I may set a new record by being the first to sleep during my own talk on Thursday.

tgenahmet @tgenahmet

This talk has the word tera-base in title :-) #bg2011