起立性調節障害とコロナ後遺症

Dr Claire Taylor @drclairetaylor

@1goodtern No but I have now 😀 I’m always a bit sceptical of ‘one theory’ and more inclined to think there are a few things going on. Interesting and surely has merit 👏

Marya Alexander, MD @maryaalexand1

@drclairetaylor How do you choose to test for POTS? Other than 10 minute stand test, do you next reach for NASA lean test? I’ve seen patient reports that when they did tilt table test they permanently worsened their baseline. Seems like best idea is to stop any tests as soon as criteria is met.

Dr Claire Taylor @drclairetaylor

@maryaalexand1 Personally I only do 10 Min stand. Often has to be abandoned before 10 mins as too symptomatic and diagnosis is reached. Can use stand or lean. I only do tilt if suspect POTS and stand test is Normal.

PoTS UK @UKPoTS

@drclairetaylor Excellent thread as always @drclairetaylor 🙌🏻 For those who would like to learn more about #PoTS, please visit our website: potsuk.org

Dr Claire Taylor @drclairetaylor

@UKPoTS Yes please visit @UKPoTS website it has SO much useful information.

Solenn TANGO @Eerrnn

@drclairetaylor The element that helped me the most in my long covid, except the anticoagulants, is the auricular electrostimulation (tens). I had lost 10 kg, couldn't do anything... It wasn't perfect afterwards of course, but it clearly helped a lot with bowel and vagal issues

Dr Claire Taylor @drclairetaylor

@Eerrnn Interestingly some people find it makes it worse. Seems Person dependent

Marlene Robin @TheVitalClub

@drclairetaylor Can you list the medication please so I can show it to my general practitioner. He is willing to help.

Dr Claire Taylor @drclairetaylor

@TheVitalClub potsuk.org/managingpots/m…

Jo @cfs_jo

@drclairetaylor @1goodtern I have steadily improved over the past 18 months by paying attention to my vagus nerve. Started with breathing, then humming and gargling and now use a Tens machine. It’s made a noticeable difference to me. Could be spontaneous recovery of course, but the timings coincide.

Dr Claire Taylor @drclairetaylor

@cfs_jo @1goodtern Around 18 months is what study on it would say but that’s an average. Have heard of others find humming helpful!

tern @1goodtern

@drclairetaylor Oh yeah, for absolute certain. Covid can dysregulate almost every bodily system, and each dysregulated system on its own can explain many of the problems.

Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“私たちの研究結果は、 #LongCOVIDの病態生理学に関する現在の仮説のいくつか（ウイルスリザーバー、持続性炎症、凝固亢進、迷走神経機能障害）が、セロトニン減少によって結びついた単一の経路によって結びついている可能性があることを示唆しています。 (8 /10）” x.com/MaayanLevy_Lab…

Maayan Levy @MaayanLevy_Lab

Our findings suggest that several of the current hypotheses for the pathophysiology of #LongCOVID (viral reservoir, persistent inflammation, hypercoagulability, vagus nerve dysfunction) might be linked by a single pathway that is connected by serotonin reduction. (8/10) pic.twitter.com/cVjq4OWa2N

2023-10-16 23:54:17

Maayan Levy @MaayanLevy_Lab

We are excited to share our new work @CellCellPress, led by Andie Wong, in collaboration with the groups of Ben Abramoff, Sara Cherry, and @ThaissLab, uncovering a multi-organ pathway with important implications for the pathogenesis of #LongCOVID. (1/10) cell.com/cell/fulltext/…

Maayan Levy @MaayanLevy_Lab

@CellCellPress @ThaissLab We followed a cohort of more than 1,500 individuals with #LongCOVID and characterized their spectrum of symptoms. We then asked whether we could identify biomarkers that distinguish individuals with Long COVID from fully recovered individuals. (2/10) pic.twitter.com/D8DdvqBPio

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Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“Andie Wong が率いる Ben Abramoff、Sara Cherry、@ThaissLabのグループと共同で行った新しい研究@CellCellPressを発表できることを嬉しく思います。この研究では、 #LongCOVID の病因に重要な意味を持つ多臓器経路が明らかにされました。(1/10)” x.com/MaayanLevy_Lab…

Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“私たちは #LongCOVID の 1,500 人以上のコホートを追跡し、症状の範囲を特徴づけました。次に、ロング COVID の患者と完全に回復した患者を区別するバイオマーカーを特定できるかどうかを検討しました。(2/10)” x.com/MaayanLevy_Lab…

Maayan Levy @MaayanLevy_Lab

We assessed the metabolite profile of individuals with #LongCOVID and identified #serotonin as a molecule whose abundance is reduced both during acute COVID-19 and in individuals with multiple long-term symptoms. (3/10) pic.twitter.com/tR4zfEonjb

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Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“私たちは#LongCOVIDの個人の代謝プロファイルを評価し、急性COVID-19の期間中と複数の長期症状を持つ個人の両方で存在量が減少する分子として#serotoninを特定しました。（3/10）” x.com/MaayanLevy_Lab…

Maayan Levy @MaayanLevy_Lab

The phenomenon of serotonin reduction was not unique to SARS-CoV-2 infection, since we also observed it in humans and mice acutely or chronically infected with other viruses, and even in mice treated with the viral RNA mimetic poly(I:C). (4/10) pic.twitter.com/Z1zrRSUWrO

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Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“セロトニン減少の現象はSARS-CoV-2感染に特有のものではなく、他のウイルスに急性または慢性感染したヒトやマウス、さらにはウイルスRNA模倣ポリ(I:C). ( 4/10で治療したマウスでも観察された。” x.com/MaayanLevy_Lab…

Maayan Levy @MaayanLevy_Lab

How do viral infections result in serotonin reduction? We found that type I interferon signaling was required, which is interesting in light of recent reports suggesting that viral persistence and sustained elevation of interferons are characteristic of #LongCOVID. (5/10) pic.twitter.com/WuwxAwHo4t

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Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“ウイルス感染はどのようにしてセロトニン減少を引き起こすのでしょうか? ウイルスの持続とインターフェロンの持続的な上昇が#LongCOVIDの特徴であると示唆する最近の報告を考慮すると、I 型インターフェロンシグナル伝達が必要であることが興味深いことがわかりました。(5/10)” x.com/MaayanLevy_Lab…

Maayan Levy @MaayanLevy_Lab

How do interferons drive serotonin reduction? Three mechanisms: (1) reduced intestinal uptake of tryptophan, the biosynthetic precursor of serotonin; (2) reduced counts of platelets, which carry serotonin in the circulation; (3) enhanced enzymatic turnover of serotonin. (6/10) pic.twitter.com/zJDoHv6F1O

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Cook⚡規制解除（ただしいつ規制入るかわからない！） @CookDrake

“インターフェロンはどのようにしてセロトニンの減少を促進するのでしょうか? 3 つのメカニズム: (1) セロトニンの生合成前駆体であるトリプトファンの腸管吸収の減少、(2) 循環系でセロトニンを運ぶ血小板数の減少、(3) セロトニンの酵素代謝の促進。(6/10)” x.com/MaayanLevy_Lab…