確率的影響

Seiichi Ushikubo @sushikubo

いろいろな修飾・修正を経ているものの、UNSCEAR 1993 に書かれた Single-hit target theory をベースにしているのかと思ったのだけど、違うのかな。

Seiichi Ushikubo @sushikubo

Single-hit target theory (UNSCEAR 1993 REPORT. Influence of dose and dose rate on stochastic effects .. p620~ http://t.co/r39tNAng )

Seiichi Ushikubo @sushikubo

single-hit target theory. UNSCEAR 1993 ANNEX F (31) http://t.co/eOPBzmja

拡大

Seiichi Ushikubo @sushikubo

single-hit target theory. UNSCEAR 1993 ANNEX F (31) 続き http://t.co/vS7fOy1N

拡大

Seiichi Ushikubo @sushikubo

UCSCEAR 2010. (28) the process starts by the change of one or more genes of the DNA of a single “stem-like” cell i... http://t.co/lwb4RTpX

Seiichi Ushikubo @sushikubo

ICRP 99 のCONCLUSIONS には、確かに "including the dose delivered by a single photon" て書いてあるんだよな。まあ、限りなくゼロに近い確率だろうけど。

Seiichi Ushikubo @sushikubo

ICRP 99 (75) "the fundamental questions at the cell and molecular level to be considered for understanding risks at low doses are: ..." cont

Seiichi Ushikubo @sushikubo

ICRP 99 (75) "... (1) whether the damage caused by radiation is similar or distinct from endogenous damage; ..."

Seiichi Ushikubo @sushikubo

ICRP 99 (75) "... (2) does damage occur at low doses/dose rates by IR that cannot be repaired accurately; "

Seiichi Ushikubo @sushikubo

ICRP 99 3.6. Conclusions (121) "IR is able to produce a unique type of damage in which multiple lesions are encountered within ...."

Seiichi Ushikubo @sushikubo

ICRP 99 (121) "Even a single track of IR through a cell is likely to induce these unique clustered damages."

Seiichi Ushikubo @sushikubo

ICRP 99 (121) "This type of damage is unlikely to be frequently generated endogenously or by other exogenous agents, ..."

Seiichi Ushikubo @sushikubo

ICRP 99 (121) "... and thus there may not have been a strong selective pressure driving efficient repair."

Seiichi Ushikubo @sushikubo

ICRP 99 (121) "Although cells have a vast array of damage response mechanisms ..."

Seiichi Ushikubo @sushikubo

ICRP 99 (121) "that facilitate the repair of DNA damage and the removal of damaged cells, these mechanisms are not foolproof."

Seiichi Ushikubo @sushikubo

おおざっぱに言えば、（１）放射線によるDNA損傷は、活性酸素等による内因性の損傷と異なっている。（２）DNAの修復機構や損傷細胞の排除の機構は完全ではない、という事。なんでこんなにつかれているのにこんなことつぶやいているのだろう。

Seiichi Ushikubo @sushikubo

低線量での線量と線量率についての基本的な考え方：UNSCEAR 1993 ANNEX F. Influence of dose and dose rate on stochastic effects of radiaion. より

Seiichi Ushikubo @sushikubo

UNSCEAR 1993 ANNEX F. (39) "The dose response should be independent of dose rate, because the time interval between tracks is irrelevant .."

Seiichi Ushikubo @sushikubo

UNSCEAR 1993 ANNEX F. (39) ".. if the tracks are acting totally independently."

Seiichi Ushikubo @sushikubo

UNSCEAR 1993. ANNEX F (42) "Dose region I (low-dose region). In this dose region there are so few radiation tracks ..."

Seiichi Ushikubo @sushikubo

UNSCEAR 1993 ANNEX F (42) "... that a single cell (or nucleus) is very unlikely to be traversed by more than one track."

Seiichi Ushikubo @sushikubo

UNSCEAR 1993 ANNEX F (42) "In this region of 'definite' single-track action, the dose response for single-cell effects is ..."

Seiichi Ushikubo @sushikubo

UNSCEAR 1993 ANNEX F (42) "... almost bound to be linear and independent of dose rate."