小児の甲状腺がん

疫学・臨床像を中心に 放射線関連の小児甲状腺がんと放射線被ばく歴のない小児甲状腺がんとの間には、臨床像・予後に差がないことが知られている。(Tuttle RM 2011) 小児甲状腺がんの頻度は少ないが、その臨床像は判ってきている (Ito Y. Kuma Hospital 2012)。
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Seiichi Ushikubo @sushikubo

@myen Bauer (2006) "as many as 50% of children with thyroid cancer present with persistent cervical adenopathy as their initial symptom"

2013-02-20 22:22:35
Seiichi Ushikubo @sushikubo

@myen Bauer (2006) "At the time of diagnosis, 30–70% of these patients have palpable lymph nodes, ..."

2013-02-20 22:29:01
Seiichi Ushikubo @sushikubo

@myen Bauer (2006) "... up to 90% of PTC lesions are already locally invasive at initial surgery, most commonly .. to regional lymph nodes."

2013-02-20 22:31:22
Seiichi Ushikubo @sushikubo

@myen Bauer (2006) "Lung metastases are reported in 6–20% of children"

2013-02-20 22:32:18

James J. Figge 甲状腺がんの疫学

Seiichi Ushikubo @sushikubo

@myen James J. Figge "Epidemiology of Thyroid Cancer" In: Wartofsky L. Thyroid cancer: a comprehensive guide to ..

2013-02-20 22:48:10
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "The age-adjusted annual incidence is 68/million, with a higher incidence in women (99/million) than men (36/million)"

2013-02-20 22:53:08
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "Thyroid cancer prevalence rates vary widely by geographic area, patient population, and method of survey."

2013-02-20 22:54:21
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "Autopsy rates ranging from 0.03% to over 2% have been reported."

2013-02-20 22:55:32

直径1cm以下の小さな甲状腺乳頭がんは、”papillary microcarcinomas" と分類される。

Seiichi Ushikubo @sushikubo

@myen Figge (2006) "Small foci of papillary thyroid carcinoma, measuring 1 cm or less in diameter, ..."

2013-02-20 22:57:47
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "... can be classified as 'papillary microcarcinomas' (27) and occur frequently in autopsy material (28)"

2013-02-20 23:00:06
Seiichi Ushikubo @sushikubo

@myen Figge (2006) ref-27 LiVolsi VA. "Papillary neoplasms of the thyroid." Am J Clin Pathol 1992; 97:426– 434. http://t.co/ZqRiQxPz

2013-02-20 23:12:37
Seiichi Ushikubo @sushikubo

@myen Figge (2006) ref-28: Ain KB. "Papillary thyroid carcinoma " Endocrinol Metab Clin North Am 1995; 24:711–760. http://t.co/KKfwLlO7

2013-02-20 23:23:15

”papillary thyroid microcarcinoma”
フィンランド:33.7%、日本:20%以上

Seiichi Ushikubo @sushikubo

@myen Figge (2006) "The highest prevalence .. papillary thyroid microcarcinoma (≤1cm) was reported from Finland with 33.7% of 101 cases .."

2013-02-20 23:31:08
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "Rates over 20% have been reported from Japan (35,36)"

2013-02-20 23:31:43
Seiichi Ushikubo @sushikubo

@myen Figge "Minute papillary carcinomas (<5 mm) are rarely detected clinically and are believed to exhibit a relatively benign .. course."

2013-02-20 23:33:31
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "However, there are occasional reports of distant metastases that arise from minute papillary carcinomas."

2013-02-20 23:34:49
Seiichi Ushikubo @sushikubo

@myen Figge (2006) "Thyroid cancer prevalence rates are significantly greater than incidence figures ..."

2013-02-20 23:36:39
Seiichi Ushikubo @sushikubo

@myen Fugge (2006) "... reflecting that substantial numbers of patients survive several decades or longer."

2013-02-20 23:37:21

Francis H. Fukunaga Geographic pathology of occult thyroid carcinomas

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