小児の甲状腺がん
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- いいね！2
Seiichi Ushikubo
@sushikubo
@myen Poth (2006) "Both the presentation and behavior of thyroid cancer in children differs somewhat from that of adults."
2013-02-20 21:42:13小児の甲状腺がんの臨床像は、成人の甲状腺がんとは違っている。
小児の場合、局所への浸潤やリンパ節への広がりを起こしている人が90％。肺への遠隔転移を起こしている人が20％。
Seiichi Ushikubo
@sushikubo
@myen Poth (2006) "In children, the incidence of local invasion of tumor or spread to lymph nodes approaches 90%, ..."
2013-02-20 21:43:17
Seiichi Ushikubo
@sushikubo
@myen Poth (2006) "... and distant metastases to lung are present at diagnosis in up to 20%."
2013-02-20 21:44:06本人家族が気づくことが少なく、検診等で頚部腫瘤や甲状腺結節を発見される事が多い。
発症時に、他の症状(飲み込みにくい・声ガレ・痛み)を伴うことは少ない。
Seiichi Ushikubo
@sushikubo
@myen Poth (2006) "The discovery of a neck mass or solitary thyroid nodule most often occurs during a routine physical examination ..."
2013-02-20 21:46:33
Seiichi Ushikubo
@sushikubo
@myen Poth (2006) "... it is not uncommon for the patient or a family member to detect a mass ..."
2013-02-20 21:47:46
Seiichi Ushikubo
@sushikubo
@myen Poth (2006) "Other symptoms, such as dysphagia, hoarseness, or pain, are less common in children with thyroid cancer at presentation."
2013-02-20 21:48:35Bauer AJ. and Poth M. 小児の甲状腺の乳頭がん
Seiichi Ushikubo
@sushikubo
@myen Bauer AJ. and Poth M. "Papillary Cancer Special, Aspects in Children" In: Wartofsky L. Thyroid cancer: a comprehensive guide to ..
2013-02-20 21:56:31成人の乳頭がんと違い、小児の甲状腺乳頭がんは、局所浸潤しやすく、発症時に肺へ遠隔転移を起こしているもとも多い。
初回治療の後の再発の頻度も高い。
にもかかわらず、5年生存率と10年生存率は非常に高い。
Seiichi Ushikubo
@sushikubo
@myen Bauer (2006) "In contrast to adults, however, pediatric patients with PTC have more locally invasive disease ..."
2013-02-20 21:58:50
Seiichi Ushikubo
@sushikubo
@myen Bauer (2006) "... and more pulmonary metastases at presentation, ..."
2013-02-20 22:00:39
Seiichi Ushikubo
@sushikubo
@myen Bauer (2006) "... as well as a higher incidence of recurrent or persistent disease after initial treatment."
2013-02-20 22:01:22
Seiichi Ushikubo
@sushikubo
@myen Bauer (2006) "... 5- and 10-yr survival rates and disease-specific mortality for children with PTC remains favorable."
2013-02-20 22:03:16甲状腺結節を触れる事は小児では多くない。組織学的に2%以下の"prevalence"と報告されている。
Seiichi Ushikubo
@sushikubo
@myen Bauer "Thyroid nodules are thought to be relatively uncommon in children, historically reported at a prevalence of less than 2% (17)"
2013-02-20 22:06:17
Seiichi Ushikubo
@sushikubo
@myen Bauer ref-17 Bentley AA "Evaluation and management of a solitary thyroid nodule in a child." Otolaryngol Clin N Am 2003; 36: 117–128.
2013-02-20 22:07:54
Seiichi Ushikubo
@sushikubo
@myen Bentley "Evaluation and management of a solitary thyroid nodule in a child" Otolaryngol Clin N Am 2003;36: 117. http://t.co/q4jxDaYc
2013-02-20 22:11:20成人の甲状腺結節と違い、小児の甲状腺結節の50%は悪性かもしれない。
Seiichi Ushikubo
@sushikubo
@myen Bauer (2006) "Unlike nodular thyroid disease in adults, up to 50% of pediatric thyroid nodules may be malignant (18,19)."
2013-02-20 22:14:01
Seiichi Ushikubo
@sushikubo
@myen Bauer ref-18: Hopwood NJ. "Thyroid masses: approach to diagnosis and ..." Pediatr Rev 1993; 14: 481– 487. http://t.co/PA8YoQml
2013-02-20 22:17:05
Seiichi Ushikubo
@sushikubo
@myen Bauer ref-19: Hung W. "Solitary thyroid nodules in 71 children and adolescents" J Pediatr Surg 1992;27:1407–. http://t.co/Sghc9p0n
2013-02-20 22:19:58小児甲状腺乳頭がんの臨床像