HMP2010-09-01
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- いいね！0
McDonnell Genome Institute
@GenomeInstitute
W Zhang: Future direction: working on measuring 100 genes from a single cell #HMP2010
2010-09-02 05:30:32
McDonnell Genome Institute
@GenomeInstitute
W Zhang: Technology has been developed to cheaply and easily measure gene expression in single bacterial and eukaryotic cells. #HMP2010
2010-09-02 05:31:08
McDonnell Genome Institute
@GenomeInstitute
Fredric Bushman from U Penn on changes in microbial populations of the human gut associated with diet #HMP2010
2010-09-02 05:37:27
McDonnell Genome Institute
@GenomeInstitute
Bushman: Inflammatory Bowel Diseases (IBD) Crohn's, ulcerative colitiis etc. affect 1 million in US; may be due to diet #HMP2010
2010-09-02 05:38:47
McDonnell Genome Institute
@GenomeInstitute
Bushman: in kids, simplified diet for pediatric Crohn's has been quite successfull but mechanism is unclear #HMP2010
2010-09-02 05:39:54
McDonnell Genome Institute
@GenomeInstitute
Bushman: 16S tag sequencing on patients with controlled diet #HMP2010
2010-09-02 05:42:34
McDonnell Genome Institute
@GenomeInstitute
Bushman: study of diet & stool #microbiome composition using questionaires of usual and recent diet in 100 subjects #HMP2010
2010-09-02 05:45:02
McDonnell Genome Institute
@GenomeInstitute
Bushman: diet affecting #microbiome - fiber, CLAs, lactose all affect gut microbes #HMP2010
2010-09-02 05:47:05
McDonnell Genome Institute
@GenomeInstitute
Bushman: specific dietary components correlated with specific bacterial species in human gut #HMP2010
2010-09-02 05:47:53
McDonnell Genome Institute
@GenomeInstitute
Bushman: could also recover viral DNA from human guts with controlled diets #HMP2010
2010-09-02 05:48:51
McDonnell Genome Institute
@GenomeInstitute
Bushman: your poop has 10 to the 10 viral particles per gram #HMP2010
2010-09-02 05:49:47
McDonnell Genome Institute
@GenomeInstitute
Bushman: people have distinctive viral communities in gut; different subjects on same diets' communities become closer #HMP2010
2010-09-02 05:54:22
McDonnell Genome Institute
@GenomeInstitute
Bushman: bacterial populations in pediatric IBD kids on elemental diet changes sharply with diet change #HMP2010
2010-09-02 05:55:56
Dr. Ruchira S. Datta is also on Mastodon
@emergentnexus
Microblogging Todd Taylor's talk on MetaBin taxonomic assignment of metagenomic sequences http://ff.im/q4fuV #HMP2010
2010-09-02 05:39:49
Jonathan Eisen
@phylogenomics
Listening to a Diane Hoffman discussing federal regulation of probiotics - there is lots of misleading stuff out there #HMP2010
2010-09-02 05:42:09
Jonathan Eisen
@phylogenomics
Hoffman: for most probiotics we know very little about effectiveness, safety, mechanisms and other key parameters #HMP2010
2010-09-02 05:44:31
Jonathan Eisen
@phylogenomics
Hoffman: whether/how to regulate probiotics depends on health claims, whether in food or not, etc. #HMP2010
2010-09-02 05:46:57
Jonathan Eisen
@phylogenomics
Many probiotics sellers make structure/function claims like "x promotes intestinal health" - these are less regulated #HMP2010
2010-09-02 05:49:24
Jonathan Eisen
@phylogenomics
Hoffman: FDA regulates health claims probiotics though FTC can also be involved if claims in media #HMP2010
2010-09-02 05:50:23
Jonathan Eisen
@phylogenomics
Hoffman: some think probiotics overregulated (making research harder); others think underregulated (bogus stuff out there) #HMP2010
2010-09-02 05:52:48
McDonnell Genome Institute
@GenomeInstitute
Zhiheng Pei from NYU on foregut #microbiome in development of esophageal adenocarcinoma #HMP2010
2010-09-02 05:58:25
McDonnell Genome Institute
@GenomeInstitute
Pei: foregut #microbiome is altered in esophageal adenocarcinoma and reflux esophagitis and Barrett's esophagus #HMP2010
2010-09-02 06:00:16
McDonnell Genome Institute
@GenomeInstitute
Pei: try to normalize #microbiome with antibiotics, replace missing species with probiotics and stop pathogenic mech in esoph dz #HMP2010
2010-09-02 06:11:33
McDonnell Genome Institute
@GenomeInstitute
Pei: look at what signal activates pathway in esophageal epithelial cells #HMP2010
2010-09-02 06:13:10
McDonnell Genome Institute
@GenomeInstitute
Pei: esophageal bacterial can indirectly activate these esophageal pathways #HMP2010
2010-09-02 06:14:25