Nikiforov ”放射線は甲状腺がんの incidence を増やすのか

kazu @Kazu031104

Nikiforov YE (2010) "Is Ionizing Radiation Responsible for the Increasing Incidence of Thyroid Cancer ?" http://t.co/aWxd6X2zPl

kazu @Kazu031104

@myen Nikiforov (2010) "The incidence of thyroid cancer has been rising at a high pace in the United States and in many other countries."

kazu @Kazu031104

@myen Nikiforov (2010) "The reasons for such a steep increase in thyroid cancer incidence are not well understood."

kazu @Kazu031104

@myen Nikiforov (2010) "The highest rate of increase is for small and localized thyroid cancers, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "... which led many to suggest that the increase is because of better cancer detection by ultrasonography ..."

kazu @Kazu031104

@myen Nikiforov (2010) "These small cancers rarely progress to a clinically relevant disease and are believed to represent an incidental .."

kazu @Kazu031104

@myen Nikiforov (2010) "However, it most likely is not the sole reason and other etiologic factors probably have played a role."

kazu @Kazu031104

@myen Nikiforov (2010) "One of the potential culprits is ionizing radiation, ..."

kazu @Kazu031104

@myen NIkiforov (2010) "... which is a major known risk factor for thyroid cancer and particularly for papillary carcinoma, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "The growing incidence of thyroid cancer over the last decades is entirely because of papillary carcinoma, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "... whereas the incidence of other thyroid cancer types remains unchanged or is decreasing."

kazu @Kazu031104

@myen Nikiforov (2010) "About half of the increase is due to tumors that are 1 cm or less in size, ... as papillary microcarcinomas."

kazu @Kazu031104

@myen Nikiforov(2010) ".. Hayashi and colleagues report .. the association between papillary microcarcinoma and .. atomic bomb survivors .."

kazu @Kazu031104

@myen Nikiforov (2010) "The study finds a statistically significant radiation-dose response for the prevalence of these tumors, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "The dominant mutation mechanism in radiation-induced tumors is chromosomal rearrangement, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "... such as those leading to the formation of RET/PTC, TRK, and BRAF/AKAP9 fusion oncogenes."

kazu @Kazu031104

@myen Nikiforov (2010) "A very different mutation mechanism, ie, point mutation, is the most prevalent in sporadic tumors, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "... which typically carry point mutations of BRAF and RAS genes."

kazu @Kazu031104

@myen Nikiforov "Of particular interest is the RET/PTC rearrangement, which is found in up to 80% of radiation-induced papillary carcinomas"

kazu @Kazu031104

@myen Nikiforov (2010) "In the study reported by Hamatani et al, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "... the presence of RET/PTC rearrangement had direct correlation with increasing radiation dose, ..."

kazu @Kazu031104

@myen Nikiforov (2010) "... whereas BRAF point mutation had strong inverse correlation with the dose."

kazu @Kazu031104

@myen Nikiforov (2010) "... additional evidence for the association between this subtype of papillary carcinoma and radiation exposure."

kazu @Kazu031104

@myen Nikiforov (2010) "the results of the study reported by Hayashi and colleagues provide evidence suggesting ..."

kazu @Kazu031104

@myen ".. that the growing incidence of small thyroid tumors may be related in part to increasing exposure of humans to ionizing radiation."