Tronko (2003) などから

Ukrainian–American Thyroid Project 概要 Tronko MD の論文を中心に (線量評価については改めて)
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Seiichi Ushikubo @sushikubo

Tronko MD (1999) "Thyroid Carcinoma in Children and Adolescents in Ukraine after the Chernobyl Nuclear Accident" http://t.co/QluZBjnE3r

2014-01-02 10:16:57

RESULTS.

Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) FIGURE 1. Incidence of thyroid carcinoma in children in Ukraine by region (1986 –1990). http://t.co/DvQFJGCW62

2014-01-02 10:19:58
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During the 5 years preceding the Chernobyl nuclear accident, a total of 59 cases of thyroid carcinoma were identified in the birth to 18 years age group (25 in children age <= 14 years and 34 in adolescents ages 15–18 years).
(チェルノブイリ事故前の5年間で、0~18歳で確認された甲状腺がんは59人だった)

Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) FIGURE 2. Incidence of thyroid carcinoma in children in Ukraine by region (1991–1995). http://t.co/sRg1zsOvur

2014-01-02 10:21:55
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Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) FIGURE 3. Incidence of thyroid carcinoma in children in Ukraine by region (1996 –1997). http://t.co/ynS689AETu

2014-01-02 10:23:15
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Between 1986 and 1997, the total number of thyroid carcinomas in Ukrainian children and adolescents was 577 (358 children and 219 adolescents).
(1986年から1997年にかけて小児期/思春期での甲状腺がんは577人だった)

Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) TABLE 1 Age and Gender Distribution of Children and Adolescents ... during 1986–1997 http://t.co/R7bYOZu1Wf

2014-01-02 10:27:47
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Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) TABLE 2 Age and Gender Distribution of Children and Adolescents ... during 1986–1997 http://t.co/UtD2WQkXP9

2014-01-02 10:28:43
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Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) TABLE 4 Incidence of Symptoms of Thyroid Carcinoma in Children Age < 15 Years http://t.co/krW7hTeisx

2014-01-02 10:30:01
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Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (1999) TABLE 5 & 6 Incidence of Thyroid Carcinoma in Children & Adolescents http://t.co/aP14wlTw7a

2014-01-02 10:32:44
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At diagnosis, many of the tumors were classified at high stages, with extrathyroidal extension.
(診断時に多くの腫瘤は進行したステージで甲状腺外への進展を伴っていた)

Most patients have been treated by total or “near total” thyroidectomy based on a preoperative cytologic diagnosis and/or an intraoperative frozen section. In addition, 61.6% of children and 38.6% of adolescents underwent unilateral or bilateral modified neck lymph node dissection for clinically enlarged lymph nodes.
(治療としては多くの患者で甲状腺全摘あるいは亜全摘が行われた)

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Ukrainian–American Thyroid Project
‘‘Protocol for the study of thyroid cancer and other thyroid disorders in Ukraine following the Chernobyl accident.’’

Seiichi Ushikubo @sushikubo

Tronko MD. (2003) "Thyroid gland and radiation" http://t.co/Mhd4hKB0hk 1998-2003年にUkraineで行われたスクリーニング検査。

2013-12-30 18:52:01
Seiichi Ushikubo @sushikubo

@myenSU Tronko (2003) "For the period 1998–2000, 13227 cohort subjects have undergone screening, ..."

2013-12-30 18:55:18
Seiichi Ushikubo @sushikubo

@myenSU Tronko MD. (2003) "... and in 2001–2002, a repeat screening was performed."

2013-12-30 18:56:24

Selection of the cohort

  1. children (aged 0 to 14) or adolescents (aged 15 to 18) at the time of the Chernobyl accident (年齢 事故時に0-18歳)
  2. thyroid monitored for gamma radiation within a few weeks after the accident (事故後数週間以内に実測された)
  3. resided at the time of the accident in the most contaminated regions of the Ukraine (事故時に汚染地域に居住していた)

(選択された汚染地域)

Seiichi Ushikubo @sushikubo

@myenSU Tronko MD. (2003) "... resided at the time of the accident in the most contaminated regions of the Ukraine:" http://t.co/HDaFb95w8m

2013-12-30 19:02:47
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(条件を満たしたのは75349人)

Seiichi Ushikubo @sushikubo

@myenSU "It was determined that 75349 persons met the required criteria in the database of thyroid measurements" http://t.co/KILLs8Lprf

2013-12-30 19:06:45
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(first selection
甲状腺線量が高い群は全員 10075 人
甲状腺線量が中程度の群から 4999 人
甲状腺線量が低い群から 4997 人)

Seiichi Ushikubo @sushikubo

@myenSU Tronko MD (2003) first selection of the cohort of study subjects http://t.co/psi4U4Om3x

2014-01-02 17:24:55
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