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- いいね！0
Seiichi Ushikubo
@sushikubo
Demidchik YE (2007) "Childhood Thyroid Cancer in Belarus, Russia, and Ukraine after Chernobyl and at Present" http://t.co/aotrSdyIcF
2013-06-30 00:28:12小児の散発性(sporadic)の甲状腺乳頭がんの二つの特徴
ひとつは、遺伝子の点変異(point mutation)の有病率よりも遺伝子の再構成(rearrangement)の有病率が多いこと。
もうひとつは放射線誘発がんに比べて遺伝子の再構成の有病率が低いこと。
遺伝子の再構成と点変異の不均衡が、異なった年齢での予後の違いの一部分を説明するかもしれない
Seiichi Ushikubo
@sushikubo
@myen Demidchih (2007) "Perhaps such an imbalance between rearrangement-type gene alterations and point mutations ...(cont)"
2013-06-30 01:08:04
Seiichi Ushikubo
@sushikubo
@myen Demidchik "(cont) ... may be a part of the explanation of the difference in the prognosis of disease in patients of different age."
2013-06-30 01:09:03
Demidchik YE (2007)
Demidchik YE (2007) "Childhood Thyroid Cancer in Belarus, Russia, and Ukraine after Chernobyl and at Present" http://www.scielo.br/pdf/abem/v51n5/a12v51n5.pdf
875 pv
2
ooooooooooooooooooooooooooooooooo
Seiichi Ushikubo
@sushikubo
EU Scientific Seminar 2010 http://t.co/f3JoN89tAY , Williams D. "Thyroid cancers after the Chernobyl accident - lessons learnt: an update"
2013-10-06 10:58:39
Seiichi Ushikubo
@sushikubo
Williams D (2010) "Thyroid cancers after the Chernobyl accident; lessons learnt, an update." http://t.co/N3X9uhNoTE
2013-10-06 11:00:12
Seiichi Ushikubo
@sushikubo
Williams D (2010) "Papillary Thyroid Carcinoma, genes and radiation dose" http://t.co/N3X9uhNoTE http://t.co/MbGx90BD7p
2013-10-06 11:02:33
拡大
Seiichi Ushikubo
@sushikubo
Williams ".. mutations due to double strand breaks are more common than point mutations as the initial event in radiation induced tumours"
2013-10-06 11:05:31ooooooooooooooooooooooooooooooooo
Seiichi Ushikubo
@sushikubo
端的にいえば、放射線被ばくは、発症者数を増やすだけでなく、遺伝子点変異(point mutation)と遺伝子再構成(rearrangement)の比率を変化させると考えました。@drsteppenwolf
2013-10-06 23:28:55単純に甲状腺等価線量が高い人ではREP/PTC再構成の頻度が高いと考えてはいけない。
LNT - Single-hit target theory から導かれることは『甲状腺の集団等価線量が同等なら発病者も同等』ということ。