posts aggrigation for "The biology of genomes" (1)
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- いいね！3
Shoa L. Clarke
@ShoaClarke
Stern: most of modEncode data not so useful. :-/ #BG2011
2011-05-13 10:55:43
Leonid Kruglyak
@leonidkruglyak
But wait...what about novelty? RT @genome_gov: DS: performed an assay invented by Gregor Mendel... ...they did a cross #bg2011
2011-05-13 10:58:23
National Human Genome Research Institute
@genome_gov
Doug Antczak: Maintenance of epigenetic imprints interspecies hybrids #bg2011
2011-05-13 10:59:01
Science Pond
@sciencepond
Now trending on Science Pond: #bg2011 http://bit.ly/mgIs8e
2011-05-13 11:00:03
National Human Genome Research Institute
@genome_gov
DA: genetic studies in mules - one can't make an F2, that didn't stop the study, it just made it "harder" #bg2011
2011-05-13 11:00:20
Brendan Maher
@bmaher
Mules as a genetic model? But you can't make an f2! Stubbornness from Doug Antczak at #bg2011
2011-05-13 11:00:51
Daniel MacArthur
@dgmacarthur
Doug Antczak is talking about epigenetic imprinting in mules. Notes genetics in mules is tough: can't make an F2. #bg2011
2011-05-13 11:00:54
@mickeyatwal
Antczak: problem with studying genetics of mules - no F2 generations possible! #bg2011
2011-05-13 11:01:34
Daniel MacArthur
@dgmacarthur
DA: evidence from human disease and mouse fetuses indicates the paternal genome controls placental growth. #bg2011
2011-05-13 11:02:44
Shoa L. Clarke
@ShoaClarke
Stern: shavenbaby has special place in developmental network. gets used repeatedly to pattern trichomes in highly diverged species #BG2011
2011-05-13 11:03:26
Daniel MacArthur
@dgmacarthur
DA wins the oldest slide competition: figure of gonadotrophin levels in horse/donkey/mule published in 1969. #bg2011
2011-05-13 11:04:25
National Human Genome Research Institute
@genome_gov
DA: Effect of imprinting and parent of origin on development of placenta. #bg2011
2011-05-13 11:05:58
National Human Genome Research Institute
@genome_gov
DA: Using RNA-seq data, 93 imprinted genes detected #bg2011
2011-05-13 11:07:25
Daniel MacArthur
@dgmacarthur
DA: did RNA-seq in mule - 93 genes showed biased expression from either the horse or donkey parent. #bg2011
2011-05-13 11:08:06
National Human Genome Research Institute
@genome_gov
Tal Dagan: cumulative impact of chaperone-mediated folding on genome evolution #bg2011
2011-05-13 11:16:53
National Human Genome Research Institute
@genome_gov
TD: chaperones buffer genetic variation; mutations could exist, but chaperones compensate #bg2011
2011-05-13 11:19:59
Brendan Maher
@bmaher
Tal Dagan's hypothesis: chaperones buffer the maladaptive effects of mutations, increase evolutionary rate for substrates #bg2011
2011-05-13 11:21:53
Luke Ward
@Luke__Ward
TD: do proteins that rely on chaperones to fold evolve faster (because of the buffering effect on mutations?) #bg2011
2011-05-13 11:23:33
National Human Genome Research Institute
@genome_gov
TD: chaperonin-assisted folding increases evolutionary rate (in E. coli) #bg2011
2011-05-13 11:23:52
Brendan Maher
@bmaher
TD: signal clear in bacteria. Harder to pick apart in yeast - chaperone machinery much more complex #bg2011
2011-05-13 11:26:22
National Human Genome Research Institute
@genome_gov
TD: in yeast? chaperone-substrate interactions network more complex; some chaperones are promiscuous #bg2011
2011-05-13 11:27:46
Larry Parnell
@larry_parnell
Interesting ? indeed @luke__ward TD: do proteins that rely on chaperones 2 fold evolve faster b/c of buffering effects on mutations? #bg2011
2011-05-13 11:28:19
Brendan Maher
@bmaher
So, she does network analysis. Modules of promiscuous chaperone-substrate evolve at different rates #bg2011
2011-05-13 11:30:02
National Human Genome Research Institute
@genome_gov
TD: substrate evolutionary rate found to correlate with chaperone "promiscuousness" #bg2011
2011-05-13 11:33:06