posts aggrigation for "The biology of genomes" (1)
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- いいね！3
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 Shouldn't that be "favors strong alleles?" Anyway...
2011-05-13 10:08:58
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Need a model to disentangle gBGC and selection
2011-05-13 10:09:20
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Model from Nagylaki 1983
2011-05-13 10:10:09
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Two parameters: S for selection (neg or pos); B for bias (W or S)
2011-05-13 10:10:39
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 And now some equations.
2011-05-13 10:11:10
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: gBGC favors W->S even under negative selection
2011-05-13 10:11:54
@jeannegarb
“@leonidkruglyak: Indeed MT @dgmacarthur: If you want to study evolution, do it in yeast. #bg2011”
2011-05-13 10:12:17
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: 4 alignment models: 1. null 2. gBGC 3. acceleration (selection only) 4. Acceleration and gBGC. Compare likelihoods of these
2011-05-13 10:13:00
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Analyzing 202 HARs: most fall in selection classes--most with positive selection. Also some where gBGC is most likely
2011-05-13 10:15:19
Shoa L. Clarke
@ShoaClarke
Kostka models gBGC & selection together & looks for accelerated regions which cant be accounted for by gBGC under likelihood model #BG2011
2011-05-13 10:15:59
Shoa L. Clarke
@ShoaClarke
Kostka 118/202 HARs are likely true positive selection. #BG2011
2011-05-13 10:16:58
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Use this to prioritize follow-up experiments on HARs. Adam Siepel's lab will add gBGC detection into models of codon evolution
2011-05-13 10:17:32
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Available in rphast (http://compgen.bscb.cornell.edu/phast/)
2011-05-13 10:18:06
National Human Genome Research Institute
@genome_gov
DK: human accelerated regions; ~200 analyzed; many with positive selection #bg2011
2011-05-13 10:18:26
Beth Shapiro
@bonesandbugs
tweets from #bg2011 are making me sad to be in AL. But - I feel the need to point out that you CAN study evolution outside a model system!
2011-05-13 10:19:10
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: We've also looked at accelerated regions in yeast and other species but with gBGC.
2011-05-13 10:22:47
National Human Genome Research Institute
@genome_gov
David Stern: genetics of speciation in Drosophila #bg2011
2011-05-13 10:43:23
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
After a quick break, and much ribbing from @rozowsky, back to Twitter! #bg2011
2011-05-13 10:44:15
National Human Genome Research Institute
@genome_gov
DS: performed an assay invented by Gregor Mendel... ...they did a cross #bg2011
2011-05-13 10:45:05
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
David Stern: Drosophila speciation #bg2011
2011-05-13 10:46:14
Shoa L. Clarke
@ShoaClarke
Stern: enhancers driving overlapping expression patterns are very common in eukaryotes. #BG2011
2011-05-13 10:47:18
Shoa L. Clarke
@ShoaClarke
Stern: nice example of redundant enhancers offering robustness to environmental variation encountered during development #BG2011
2011-05-13 10:48:12
Orli Bahcall
@obahcall
David Stern on phenotypic robustness and morphological evolution in Drosophila. #bg2011
2011-05-13 10:48:18
Shoa L. Clarke
@ShoaClarke
Stern: redundant enhancers are observably epistatic at local level ~400 bp. #BG2011
2011-05-13 10:50:14