posts aggrigation for "The biology of genomes" (1)
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- いいね！3
National Human Genome Research Institute
@genome_gov
GL: Sterility confers a selective advantage in yeast. #bg2011
2011-05-13 09:49:59
Daniel MacArthur
@dgmacarthur
GL: can engineer mutations into yeast that make them sterile, but give selective advantage in asexual reproduction. #bg2011
2011-05-13 09:50:43
National Human Genome Research Institute
@genome_gov
GL: The experiment = watch sterile strains arise and move through populations. 1000 generations. #bg2011
2011-05-13 09:52:18
Daniel MacArthur
@dgmacarthur
GL: set up experimental evolution system: 2 different mutations, 600 separate populations, 1000 generations. #bg2011
2011-05-13 09:52:35
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 GL: In yeast, sterile mutations have a fitness advantage
2011-05-13 09:53:47
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
Greg Lang's web page http://www.genomics.princeton.edu/glang/research.htm #bg2011
2011-05-13 09:54:06
Sally Church
@MaverickNY
Great stuff MT @NatureNews: Biology of the Genome at CSHL @michaelhoffman @dgmacarthur @obahcall @kbradnam @luke_ward @larry_parnell #bg2011
2011-05-13 09:57:46
@naturenews
There are more great people at biology of the genome: @lukejostins @genome_gov ... and I'm sure others that I'm missing #bg2011
2011-05-13 09:59:25
National Human Genome Research Institute
@genome_gov
GL: sequenced population undergoing a selective sweep at different timepoints using the Illumina platform #bg2011
2011-05-13 09:59:59
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 GL is able to use sequencing to find out exactly what is going on in the strains with selective advantage. Very cool.
2011-05-13 10:01:16
National Human Genome Research Institute
@genome_gov
GL: ultimate fate of beneficial mutations depend on background genetic landscape in which they occur #bg2011
2011-05-13 10:01:24
Daniel MacArthur
@dgmacarthur
Nice images: mutations rising and falling, competing with each other. If you want to study evolution, do it in yeast. #bg2011
2011-05-13 10:03:00
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
Rich Kostka: Distinguishing selection from GC-biased gene conversion in human accelerated Regions (Katie Pollard lab, UCSF) #bg2011
2011-05-13 10:03:44
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: What is genomic basis for phenotypic differences? What sequences have human-specific adaptations?
2011-05-13 10:04:09
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Human accelerated regions (HARs) short non-coding elements conserved in mammals--most amongst vertebrates.
2011-05-13 10:04:55
Brendan Maher
@bmaher
GL talk reminds me of our 'hopeful monster' feature http://bit.ly/e0vlTL Beneficial mutations aren't rare, but background counts. #bg2011
2011-05-13 10:04:56
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: 1. Conservation in mammals => Function. 2. Divergence in human branch => Adaptation.
2011-05-13 10:05:19
Orli Bahcall
@obahcall
Greg Lang set up long term evolution experiment in yeast to examine fate of new beneficial mutations. 600 popltns, 1000 generations.#bg2011
2011-05-13 10:05:29
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: Example: Human version of HAR #2 acts as an enhancer in limb. Chimp HAR2 does nothing. Prabhakar[1au] 2008
2011-05-13 10:06:26
National Human Genome Research Institute
@genome_gov
Denis Kostka taking the stage: GC-based gene conversion versus selection in human accelerated regions #bg2011
2011-05-13 10:06:45
Shoa L. Clarke
@ShoaClarke
Hopefully Kostka is going to address a long running debate about detecting adaptive selection in enhancers vs biased gene conversion #BG2011
2011-05-13 10:07:13
Larry Parnell
@larry_parnell
RK: Human accelerated regions (HARs) from Pollard lab and role in phenotype diversity when HAR has a SNP #BG2011 Presented here in 2009?
2011-05-13 10:07:30
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: common W->S ([AT]->[CG]) pattern.
2011-05-13 10:07:32
Leonid Kruglyak
@leonidkruglyak
Indeed MT @dgmacarthur: If you want to study evolution, do it in yeast. #bg2011
2011-05-13 10:07:34
Michael Hoffman @michaelhoffman.bsky.social
@michaelhoffman
#bg2011 RK: gBGC (or BGC_GC) can explain it--favors weak alleles
2011-05-13 10:07:59