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uchida_kawasaki
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Hensley Lab
@SCOTTeHENSLEY
Our new paper showing that some humans possessed non-neutralizing antibodies against SARS-CoV-2 prior to the COVID-19 pandemic is now up at @medrxivpreprint. Importantly, we find that these antibodies are not associated with SARS-CoV-2 protection. 1/7 medrxiv.org/content/10.110…
2020-11-11 02:35:23Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection | medRxiv https://www.medrxiv.org/content/10.1101/2020.11.06.20227215v1
季節性ヒトコロナウイルス抗体はSARS-CoV-2感染時にブーストされますが、防御には関連しません
Hensley Lab
@SCOTTeHENSLEY
Our data have some similarities but some key differences with a paper published last week @ScienceMagazine. 2/7 science.sciencemag.org/content/early/…
2020-11-11 02:35:23上記ツイート内リンクの論文に関するまとめ⬇
【science】ヒトにおけるSARS-CoV-2に対する既存および新規の交差反応性抗体(子供、若年層が重症化しにく..
忘れてはいけない事
若年層であれ無症状感染者はウイルス排出する事。
重症化する事例もある事。
722 pv
7
Hensley Lab
@SCOTTeHENSLEY
In our study: 1. We did not find that kids had higher levels of pre-pandemic SARS-CoV-2 cross-reactive antibodies compared to adults. 2. We found that pre-pandemic SARS-CoV-2 cross-reactive antibodies were non-neutralizing. 3/7 pic.twitter.com/xkD4rBjxPd
2020-11-11 02:35:24
拡大
Hensley Lab
@SCOTTeHENSLEY
3. Most importantly, we were able to measure Abs in a super unique cohort: individuals who donated serum prior to the pandemic who subsequently went on to become infected with SARS-CoV-2. Pre-pandemic cross-reactive SARS-CoV-2 Abs did not correlate with SARS-CoV-2 protection. 4/7 pic.twitter.com/Dn2DB1NYX8
2020-11-11 02:35:25
拡大
Hensley Lab
@SCOTTeHENSLEY
Our data seem consistent with this paper from @PaulBieniasz recently posted on @medrxiv 5/7 medrxiv.org/content/10.110…
2020-11-11 02:35:25
Hensley Lab
@SCOTTeHENSLEY
It will be important for us to figure out why there are differences between our study and the @ScienceMagazine study. The @ScienceMagazine study looks really solid. Could there be geographical differences in HCoV exposures or other factors that we are not thinking about? 6/7
2020-11-11 02:35:26
Hensley Lab
@SCOTTeHENSLEY
Great work lead by @NeAnder349 , Eileen Goodwin, Anurag Verma and our incredible team at @PennMedicine. In the meantime, everyone should try to stay vigilant about social distancing and mask wearing until we can get these promising COVID-19 vaccines approved and distributed. 7/7
2020-11-11 02:35:26
Prof. Akiko Iwasaki
@VirusesImmunity
This important new study by @ScotteHENSLEY examining 36 children (age 1-17) and 168 adults (age 18-90) shows that pre-pandemic cross-reactive antibodies do not confer protection against #SARSCoV2 infection or #COVID19 disease severity. twitter.com/scottehensley/…
2020-11-12 05:05:44
Eric Topol
@EricTopol
Now we know the answer to key unresolved questions. Thanks @VirusesImmunity twitter.com/VirusesImmunit…
2020-11-12 05:46:45
Dr. T.R. Raju
@TRRaju1
@VirusesImmunity @SCOTTeHENSLEY I wonder whether it is universally applicable. It will be interesting to study South Asians and African populations from endemic areas where different pathogens exist. Just a thought. I could be wrong
2020-11-12 23:34:23
Prof. Akiko Iwasaki
@VirusesImmunity
@TRRaju1 @SCOTTeHENSLEY I think this is an excellent question, @TRRaju1. There may be regional differences in how cross-reactive antibodies work to protect against #COVID19.
2020-11-13 00:23:03
fdzaraf
@fdzaraf
「新しい重要な研究は、子供(1~17歳) 36人と成人(18~90歳) 168人を調べたパンデミック前の交差反応性抗体が #新型コロナウイルス 感染症またはCOVID-19疾患の重症度に対する防御に寄与しないことを示しています。」 twitter.com/VirusesImmunit…
2020-11-12 14:53:52
fdzaraf
@fdzaraf
季節性･ヒト･コロナウイルスの抗体は、新型コロナウイルスの感染により上昇するが、防御とは関連しない medrxiv.org/content/10.110… #新型コロナウイルス 「季節性コロナウイルス交差反応性抗体はSARS‐CoV‐2感染により増強された。」 ということは感冒コロナウイルス風邪はひかなくなりますね。
2020-11-12 15:03:11
内山直
@uchiyamasunao
「季節性ヒトコロナウイルス抗体は新型コロナ感染を防ぐのに機能せず」とのふたつ（！）の論文。 交差免疫説は否定的と考えていいようです。 ①medrxiv.org/content/10.110… ②medrxiv.org/content/10.110…⬇️
2020-11-13 11:31:00⬆のツイート内の最初のリンクはPDF。論文プレプリント掲載ページは↓
Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection | medRxiv https://www.medrxiv.org/content/10.1101/2020.10.08.20209650v1
最近の季節性コロナウイルス感染者のパンデミック前の血清におけるSARS-CoV-2中和活性の欠如
内田
@uchida_kawasaki
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection | medRxiv medrxiv.org/content/10.110… 季節性ヒトコロナウイルス抗体はSARS-CoV-2感染時にブーストされますが、防御には関連しません
2020-11-12 06:58:29
内田
@uchida_kawasaki
この論文と真逆？ 【science】ヒトにおけるSARS-CoV-2に対する既存および新規の交差反応性抗体(子供、若年層が重症化しにくい理由か)(2020.11.10作成) togetter.com/li/1620843 twitter.com/uchida_kawasak…
2020-11-12 07:00:16