NGS12

SR: Genia founded in 2009 w/ 18 employees currently. Operationalizing protein nanopore-based sequencing (w/ biological sensors). #NGS12

2012-08-15 22:49:53

SR Genia: Need Dx seq tests to be < $100 run and machines < $1000 to make sequencing ubiquitous in doctors office #NGS12

2012-08-15 22:49:37

Mary Ann Brown @mab_chi

poster presentation Dario Motti, Miami Project to Cure Paralysis on using RNA-Seg to detect RNA 'actions in regenerating neurons #ngs12

2012-08-15 22:47:40

Roever: Criteria for MDx: Accuracy, Throughput, flexible panels, ease of use, cost. On flexibility - after WGS 'just a software Q' #NGS12

2012-08-15 22:47:21

Bio-IT World @bioitworld

Stefan Roever (Genia): MDx today: Dozens platforms, >1500 labs, 100s companies ->costly 1-gene tests. Solution? Sequence everything. #NGS12

2012-08-15 22:45:32

SR Genia: blood test analogy with CBC/CMP12 for $89. Wants to move to WGS for same price, w/ electrical single molecule platform. #NGS12

2012-08-15 22:45:04

Rosentein: Here's his Nature Methods 2012 reference. http://t.co/CgsMdUjM #NGS12

2012-08-15 22:44:00

SR Genia: How do you fix healthcare? Just sequence EVERYTHING!!! All the time!!! :) If only it was that simple... #NGS12

2012-08-15 22:43:12

Roever talking now from Genia Technologies -- prob. w/ scaling for pers. medicine. Need to seq everything. #NGS12

2012-08-15 22:42:54

Stefan Roever from Genia tech: Integrated circuit for nanopore sequencing. Will be commercially available in next year or two. #NGS12

2012-08-15 22:41:53

Roever: 3 assertions, first is 'DNA sequencing will dominate MDx', SMS will be the best approach, Genia's nanopore ICs ideal for MDx #NGS12

2012-08-15 22:41:22

S. Roever: "Solving the Challenges of DNA Sequencing for Molecular Diagnostics" #NGS12

2012-08-15 22:39:32

JR: Not a lot of focus on using advanced CMOS eletronics in nanopores, rather focusing on chemistry with slower detection electronics #NGS12

2012-08-15 22:39:17

Bio-IT World @bioitworld

Jacob Rosenstein (Columbia): Dry subject but very nice overview of electronic engineering of solid-state nanopore sequencing. #NGS12

2012-08-15 22:35:16

Mary Ann Brown @mab_chi

#ngs12 welcomes Stefan Roever @geniachip to the podium in the Nanopore Sequencing Session @ NGx

2012-08-15 22:34:16

Rosenstein: Conclude: electronics + chemistry are complementary. Electronics can't keep up with signals. #NGS12

2012-08-15 22:33:55

JR: Noise is largely function of capacitance in detection system (membrane, fluids and electronics). Put electrochemical on CMOS chip #NGS12

2012-08-15 22:33:24

Rosenstein: 10-15ms - 10x faster of measured events. 50bp oligos - can see diffusion, capture, threading, xloc via 1nA x 100us #NGS12

2012-08-15 22:33:14

JR: paper in Nature Methods 2012 earlier this year. Fast DNA translocation events. #NGS12

2012-08-15 22:32:38

Rosenstein: Smaller interface, integration on the 10mm scale, refer to his Nature Methods 2012 paper. #NGS12

2012-08-15 22:32:13

Rosenstein: Aim to lower noise, raise bandwidth, via CMOS preamp optimized for nanopores. #NGS12

2012-08-15 22:31:05

Rosenstein: Noise density graph: Flicker, Thermal & Shot, Dielectic loss, Capacitance. Reducing parasitic loss - lower freq noise #NGS12

2012-08-15 22:29:48

Rosenstein: Ionic capacitance the problem with nanopore + membrane. Can't do fast when electrons are stored. #NGS12

2012-08-15 22:27:50