HMP2010-09-01
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- いいね！0
McDonnell Genome Institute
@GenomeInstitute
Gordon: took fecal microbe community from healthy donor and graft it into gut of germ-free mice successfully #HMP2010
2010-09-01 23:02:25
McDonnell Genome Institute
@GenomeInstitute
Gordon: even frozen fecal samples were grafted into the germ-free mice #HMP2010
2010-09-01 23:03:14
McDonnell Genome Institute
@GenomeInstitute
Gordon examine interface between diet and structure of microbial community and degree to which human microbiome can be transplanted #HMP2010
2010-09-01 23:04:48
McDonnell Genome Institute
@GenomeInstitute
Gordon: building defined communities for sequencing with next-gen in germ-free mice guts #HMP2010
2010-09-01 23:12:40
McDonnell Genome Institute
@GenomeInstitute
Gordon: power of these defined libraries - to predict microbiota's response to host diet of defined ingredients #HMP2010
2010-09-01 23:14:49
McDonnell Genome Institute
@GenomeInstitute
Gordon: can predict species abundance/microbiota configuration with defined diets for germ-free mice #HMP2010
2010-09-01 23:16:13
McDonnell Genome Institute
@GenomeInstitute
Gordon: protein diet causes fecal DNA to increase - protein diets rule when it comes to abundance of fecal microbes #HMP2010
2010-09-01 23:17:22
McDonnell Genome Institute
@GenomeInstitute
Gordon: can transplant human gut microbiota into germ free mice and 'shake it up' by changing its diet, #HMP2010
2010-09-01 23:28:03
McDonnell Genome Institute
@GenomeInstitute
Gordon: germ-free mice can act as 'filter' for human microbiota - powerful tool #HMP2010
2010-09-01 23:28:55
McDonnell Genome Institute
@GenomeInstitute
Gordon: looking now at same microbiota from twins transplanted to germ-free mice and give all subjects the same diet #HMP2010
2010-09-01 23:30:25
McDonnell Genome Institute
@GenomeInstitute
Gordon: if take these defined communities and put in mouse, over long-term, communities persist ; don't know yet about evolution #HMP2010
2010-09-01 23:31:30
McDonnell Genome Institute
@GenomeInstitute
Gordon: on why protein 'rules' : in this context it does, plant proteins available and important; is surprising that protein ruled #HMP2010
2010-09-01 23:32:41
Jonathan Eisen
@phylogenomics
After brief delay now at #HMP2010 - Jeff Gordon up: creating artificial communities of many species & introducing to germ free animals
2010-09-01 23:13:01
Jonathan Eisen
@phylogenomics
Gordon: using defined communities of microbes to test microbiota response to different diets #HMP2010 - track changes in abundance, txn, etc
2010-09-01 23:14:28
Jonathan Eisen
@phylogenomics
Gordon : using RNAseq to track gene expression patterns in model microbial communities #HMP2010
2010-09-01 23:18:16
Jonathan Eisen
@phylogenomics
Gordon: Goal .. use "personal" culture collections isolated from people to get a collection that has coevolved w/ each other #HMP2010
2010-09-01 23:20:25
Jonathan Eisen
@phylogenomics
Gordon - much of OTU diversity in human gut microbes can be captured via culturing #HMP2010; though this ignores w/in species diversity
2010-09-01 23:21:56
Jonathan Eisen
@phylogenomics
Jeff Gordon has electrified the crowd w/ his discussion of model organisms & model communities #HMP2010 #modelorganisms
2010-09-01 23:39:58
Dr. Ruchira S. Datta is also on Mastodon
@emergentnexus
Jeff Gordon wants to go around the planet collecting human fecal samples and transplanting them into gnotobiotic mice #HMP2010
2010-09-01 23:04:05
Dr. Ruchira S. Datta is also on Mastodon
@emergentnexus
Microblogging Jeff Gordon: the marriage of comparative genomics and metagenomics http://ff.im/q2MTx #HMP2010
2010-09-01 23:07:32
MiketheMadBiologistWhoLikeTrumpAlsoHasBoxes
@mikethemadbiol
#HMP2010 Gordon: can 'humanize' mouse guts using fresh or frozen samples (presumably 'frozen' is stored in glycerol)
2010-09-01 23:05:10
MiketheMadBiologistWhoLikeTrumpAlsoHasBoxes
@mikethemadbiol
#HMP2010 ?: lots of people using linear models using 'abundance' (it's NOT abundance); is simple link function appropriate?
2010-09-01 23:16:18
MiketheMadBiologistWhoLikeTrumpAlsoHasBoxes
@mikethemadbiol
#HMP2010 Gordon is using qPCR, not 16S, to understand abundance. GOOD!
2010-09-01 23:18:03
MiketheMadBiologistWhoLikeTrumpAlsoHasBoxes
@mikethemadbiol
#HMP2010 Gordon: 70% of genera, ~60% of species found in guts CAN be cultured
2010-09-01 23:21:42
@BarbBallentine
Gordon: even frozen fecal samples were grafted into the germ-free mice #HMP2010
2010-09-01 23:30:07