HMP2010-09-01
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- いいね！0
McDonnell Genome Institute
@GenomeInstitute
Now Liping Zhao from Shanghai Center of Systems Biomedicine on re-eng. gut microbiota with TCM foods to prevent metab. syndrome #HMP2010
2010-09-01 23:37:16
McDonnell Genome Institute
@GenomeInstitute
Zhao: obesity and related disease endemic in China as well as US - interest in how diet and gut microbiota affect health #HMP2010
2010-09-01 23:38:17
McDonnell Genome Institute
@GenomeInstitute
Zhao: gut microbiota toxins may influence aging and age-related disease #HMP2010
2010-09-01 23:40:13
McDonnell Genome Institute
@GenomeInstitute
Zhao: low grade-inflammation from disrupted gut microbiota due to poor diet #HMP2010
2010-09-01 23:42:11
McDonnell Genome Institute
@GenomeInstitute
Zhao: most obese mice were wild type on high-fat diet showing didn't need genetic defect to be affected #HMP2010
2010-09-01 23:43:10
McDonnell Genome Institute
@GenomeInstitute
Zhao: diet is most important factor is shaping gut microbiota structure #HMP2010
2010-09-01 23:44:12
McDonnell Genome Institute
@GenomeInstitute
Zhao: low fat calorie restricted mice had longest lifespan compared with high fat diets #HMP2010
2010-09-01 23:46:19
McDonnell Genome Institute
@GenomeInstitute
Zhao: low fat calorie restriction (CR) group had unique gut microbiota; best aging markers; #HMP2010
2010-09-01 23:47:21
McDonnell Genome Institute
@GenomeInstitute
Zhao: lipopolysaccharide binding protein leads to inflammation from gut microbiota and is highest in high fat mice group #HMP2010
2010-09-01 23:51:06
McDonnell Genome Institute
@GenomeInstitute
Zhao: total antigens made by gut pathogens induce inflammation;optimize gut microbiota to minimize these antigens & promote health #HMP2010
2010-09-01 23:53:02
McDonnell Genome Institute
@GenomeInstitute
Zhao: more marriage (refer to Jeff Gordon's talk)- this time between metagenomics and metabolomics #HMP2010
2010-09-01 23:54:27
McDonnell Genome Institute
@GenomeInstitute
Zhao: this 'whole body system biology' used to asses and monitor human health and help understand role of gut microbiota in this #HMP2010
2010-09-01 23:56:11
McDonnell Genome Institute
@GenomeInstitute
Zhao: use Traditional Chinese Medicine (TCM), especially food to treat disease #HMP2010
2010-09-01 23:57:46
McDonnell Genome Institute
@GenomeInstitute
Zhao: was the first subject - lost weight and improved overall health as well as changing gut microbiota #HMP2010
2010-09-01 23:58:42
McDonnell Genome Institute
@GenomeInstitute
Zhao: change of gut microbiota can change immunity and metabolics to improve health #HMP2010
2010-09-02 00:02:33
McDonnell Genome Institute
@GenomeInstitute
Zhao: wishes us of all to eat right, live long and die quick #HMP2010
2010-09-02 00:04:24
Jonathan Eisen
@phylogenomics
Zhao: multiple models could explain connection between microbes and obesity #HMP2010
2010-09-01 23:42:04
Jonathan Eisen
@phylogenomics
Zhao: who is right? Grandma: you are what you eat; Geneticists: you are your genes #HMP2010
2010-09-01 23:42:50
Jonathan Eisen
@phylogenomics
Zhao: what is connection between diet, microbiome and longevity? Doing experiment in mice over four years #HMP2010
2010-09-01 23:46:14
Jonathan Eisen
@phylogenomics
Zhao: diet / excercise differences -> lifespan differences + microbiota differences; though I note just correlations right now #HMP2010
2010-09-01 23:52:14
Jonathan Eisen
@phylogenomics
Zhao emphasizes benefits of having reference genomes to sort through metagenomic data #HMP2010
2010-09-01 23:54:19
Jonathan Eisen
@phylogenomics
Zhao wants to encourage marriage of metagenomics and metabolomics in gut studies #HMP2010
2010-09-01 23:55:22
Paul Spicer
@pgspicer
At #HMP2010 All the animal models point to diet! Now there's a therapeutic application.
2010-09-02 00:31:10
McDonnell Genome Institute
@GenomeInstitute
Now Joseph Petrosino from Baylor on improved metagenomic sequencing and analysis for healthy and diseased individuals #HMP2010
2010-09-02 00:29:00
McDonnell Genome Institute
@GenomeInstitute
Petrosino: whole genome shotgun (WGS) approaches - want to better understand limitations of data sets #HMP2010
2010-09-02 00:32:36