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Eric Feigl-Ding
@DrEricDing
17) E484K mutation is also not a 1 time fluke. 🇮🇹 virologists decided to see what mutations can help virus escape from patients w/ convalescent plasma immunity. So they soaked virus w/ CP over 12x times to speed evolution—80 days later ➡️ *E484K arose*! twitter.com/ncholia/status…
2021-01-15 22:43:44
Eric Feigl-Ding
@DrEricDing
18) And the E484K mutation is carried by many #SARSCoV2 variants—both Brazil variants that arose *independently*, the South Africa 🇿🇦 B1135 variant, and the 🇮🇹 experimental forced evolution study. Converging evolution is worrisome—it means nature discovered repeatedly it works.
2021-01-15 22:47:13
Eric Feigl-Ding
@DrEricDing
19) That said, the UK B117 variant that is more infectious doesn’t have the E484K variant. It’s not more severe nor escapes antibodies, but #B117 is worrisome for different reason — its speed of domination. See thread 🧵 below. twitter.com/drericding/sta…
2021-01-15 22:48:51
Eric Feigl-Ding
@DrEricDing
⚠️CRUSH VIRUS NOW OR ELSE WE ARE SCREWED: Denmark’s CDC thinks new B117 #SARSCoV2 variant is so much more contagious (R +0.4 to +0.7) & inevitable that **if any country does not crush the R<0.7 now**, we will be completely #COVID19 screwed by Feb/March.🧵 ssi.dk/aktuelt/nyhede… pic.twitter.com/W7v1iAsgw3
2021-01-07 04:18:45