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参照文献 DNAの損傷に関して ICRP103とBEIRⅦ
Seiichi Ushikubo
@sushikubo
ICRP 103. AnnexA (A9): When DSB, SSB and base damages are considered together,
2012-01-26 01:39:22
Seiichi Ushikubo
@sushikubo
ICRP 103 cont.: complex clustered damage may constitute as much as 60% .. of total DNA damage after low .. LET radiations respectively.
2012-01-26 01:40:12
Seiichi Ushikubo
@sushikubo
ICRP 103 cont.: These data highlight a major difference between DNA lesions
2012-01-26 01:41:05
Seiichi Ushikubo
@sushikubo
ICRP 103 cont.: induced by radiation and those arising spontaneously via oxidative attack by reactive chemical radicals.
2012-01-26 01:41:26
Seiichi Ushikubo
@sushikubo
ICRP 103 cont.: Whereas the former are predominantly complex and clustered,
2012-01-26 01:42:17
Seiichi Ushikubo
@sushikubo
ICRP 103 cont.: the latter are randomly distributed and simple in their chemical structure.
2012-01-26 01:42:36
Seiichi Ushikubo
@sushikubo
ICRP 103 Annex A (A9). complex clusterd damage が low LET でDNA損傷の60％を占める。化学的に生じた活性酸素による損傷との大きな違い。
2012-01-26 01:49:46
Seiichi Ushikubo
@sushikubo
BEIR VII p45: DNA DSBs are the principal causal events for aberration induction
2012-01-26 01:55:53
Seiichi Ushikubo
@sushikubo
BEIR VII p45 cont.: and that these are induced with linear kinetics at around 30 DNA DSBs Gy–1
2012-01-26 01:56:31
Seiichi Ushikubo
@sushikubo
BEIR VII p45 cont.: The fraction of misrepair events is suggested to be dose dependent,
2012-01-26 01:59:00
Seiichi Ushikubo
@sushikubo
BEIR VII p45 cont.: with the close proximity of DNA DSBs promoting exchanges and thereby imposing curvature on the low-LET dose response
2012-01-26 01:59:29
Seiichi Ushikubo
@sushikubo
BEIR VII p45 cont. The two-track component of DNA lesion production and interaction increases as a quadratic function of dose
2012-01-26 02:00:32
Seiichi Ushikubo
@sushikubo
BEIR VII p46: .. in a very large multicenter study using assays of dicentric aberrations in human lymphocytes,
2012-01-26 02:06:55
Seiichi Ushikubo
@sushikubo
BEIR VII p46 cont.: the linearity of the response was evident down to at least 20 mGy of low-LET radiation
2012-01-26 02:07:34
Seiichi Ushikubo
@sushikubo
BEIR VII p64: Results of experiments that quantified chromosomal aberrations, malignant transformation in vitro, or mutations induced
2012-01-26 02:13:16
Seiichi Ushikubo
@sushikubo
BEIR VII p64 cont.: by relatively low total doses or low doses per fraction indicate
2012-01-26 02:14:11
Seiichi Ushikubo
@sushikubo
BEIR VII p64 cont.: that the dose-response relationship over a range of 20–100 mGy is most likely to be linear
2012-01-26 02:15:04
Seiichi Ushikubo
@sushikubo
BEIR VII p64 cont.: and not affected significantly by either an adaptive or a bystander effect.
2012-01-26 02:15:37
Seiichi Ushikubo
@sushikubo
BEIR VII p64: the question of the shape of the dose-response relationship up to about 20 mGy remains,
2012-01-26 02:19:59
Seiichi Ushikubo
@sushikubo
BEIR VII p64 cont.: although several of the dose-response relationships described above
2012-01-26 02:21:06
Seiichi Ushikubo
@sushikubo
BEIR VII p64 cont.: appear to be consistent with extrapolation linearly down to about 5 mGy.
2012-01-26 02:21:43
